Department of Sports Science, College of Education, Zhejiang University, Hangzhou 310030, China.
Department of Sports Science, College of Education, Zhejiang University, Hangzhou 310030, China.
Ageing Res Rev. 2024 Nov;101:102486. doi: 10.1016/j.arr.2024.102486. Epub 2024 Sep 6.
Alzheimer's disease (AD) is an age-related neurodegenerative disease characterized by memory impairment and cognitive dysfunction, which eventually leads to the disability and mortality of older adults. Although the precise mechanisms by which age promotes the development of AD remains poorly understood, mitochondrial dysfunction plays a central role in the development of AD. Currently, there is no effective treatment for this debilitating disease. It is well accepted that exercise exerts neuroprotective effects by ameliorating mitochondrial dysfunction in the neurons of AD, which involves multiple mechanisms, including mitochondrial dynamics, biogenesis, mitophagy, transport, and signal transduction. In addition, exercise promotes mitochondria communication with other organelles in AD neurons, which should receive more attentions in the future.
阿尔茨海默病（AD）是一种与年龄相关的神经退行性疾病，其特征是记忆障碍和认知功能障碍，最终导致老年人残疾和死亡。尽管年龄如何促进 AD 发展的确切机制仍不清楚，但线粒体功能障碍在 AD 的发展中起着核心作用。目前，这种使人衰弱的疾病还没有有效的治疗方法。人们普遍认为，运动通过改善 AD 神经元中的线粒体功能障碍来发挥神经保护作用，其中涉及多种机制，包括线粒体动力学、生物发生、自噬、运输和信号转导。此外，运动促进 AD 神经元中线粒体与其他细胞器的通讯，这在未来应该得到更多关注。
