New England Trophoblastic Disease Center, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology and Reproductive Biology, Brigham and Women's Hospital; Harvard Medical School, Boston, MA, USA; Dana-Farber Cancer Institute.
New England Trophoblastic Disease Center, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology and Reproductive Biology, Brigham and Women's Hospital; Harvard Medical School, Boston, MA, USA; Dana-Farber Cancer Institute.
Hematol Oncol Clin North Am. 2024 Dec;38(6):1287-1295. doi: 10.1016/j.hoc.2024.07.006. Epub 2024 Sep 6.
Gestational trophoblastic neoplasia (GTN) is primarily treated with chemotherapy, but surgery plays a key role at different steps in disease management, including initial diagnosis, primary therapy, and salvage options. Initial diagnosis is usually made by electric or manual vacuum aspiration for molar pregancy or uterine curettage for other forms of GTN. Excisional procedures of localized disease, whether second curettage or hysterectomy, can obviate chemotherapy, but patients still require monitoring for relapse. Resection remains a useful adjunct for either the management of isolated foci of chemoresistant disease or the management of bleeding complications.
妊娠滋养细胞肿瘤（GTN）主要采用化疗治疗，但手术在疾病管理的不同阶段都起着关键作用，包括初始诊断、一线治疗和挽救治疗方案。初始诊断通常通过电吸或手动吸引术用于葡萄胎妊娠，或刮宫术用于其他类型的 GTN。局限性疾病的切除术，无论是二次刮宫术还是子宫切除术，都可以免除化疗，但患者仍需要监测复发。切除术仍然是治疗化疗耐药病灶或出血并发症的有用辅助手段。
