Soni Manoj, Sudheer Babu Yangala, Brahma Mettle, Kumar Vijay, Maruthi Mulaka, Sharma Aastha, Nara Shikha, Sura Kiran, Dangi Mehak
Department of Biochemistry, M.D. University, Rohtak, Haryana, India.
Department of Biochemistry, Central University of Haryana, Mahendergarh, Haryana, India.
Nat Prod Res. 2024 Sep 8:1-5. doi: 10.1080/14786419.2024.2398726.
Cancer is a complex and widespread disease affecting various organs and tissues, with an expected significant increase in reported cases. Current treatments like chemotherapy and radiation therapy have limited efficacy and adverse side effects. This study investigated the multi-target therapeutic potential of seven phytochemicals against critical cancer-associated proteins. Computational docking studies analysed the binding interactions between phytochemicals and proteins, supported by in-vitro experiments on cancer cell lines. Vero cells assessed cytotoxicity, and the A549 cancer cell line evaluated anticancer activity. Cytotoxicity assessment on Vero cells revealed concentration-dependent effects of phytochemicals. Anticancer activity evaluation on the A549 cell line demonstrated the ability of certain phytochemicals to inhibit cancer cell proliferation and induce apoptosis. Cancer, Therapeutic agents, Phytochemicals, Computational docking studies, experiments, Cytotoxicity, Anticancer activity, Chemotherapy, Vero cells, A549 cell line, multi-targeted therapeutic potential, Critical cancer-associated proteins.
癌症是一种复杂且广泛传播的疾病，影响着各种器官和组织，预计报告病例数将大幅增加。当前的化疗和放疗等治疗方法疗效有限且有不良副作用。本研究调查了七种植物化学物质对关键癌症相关蛋白的多靶点治疗潜力。计算对接研究分析了植物化学物质与蛋白质之间的结合相互作用，并得到了癌细胞系体外实验的支持。用Vero细胞评估细胞毒性，用A549癌细胞系评估抗癌活性。对Vero细胞的细胞毒性评估揭示了植物化学物质的浓度依赖性效应。对A549细胞系的抗癌活性评估表明，某些植物化学物质具有抑制癌细胞增殖和诱导凋亡的能力。癌症、治疗剂、植物化学物质、计算对接研究、实验、细胞毒性、抗癌活性、化疗、Vero细胞、A549细胞系、多靶点治疗潜力、关键癌症相关蛋白。
