Department of Cardiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.
School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
J Nutr Health Aging. 2024 Oct;28(10):100353. doi: 10.1016/j.jnha.2024.100353. Epub 2024 Sep 7.
Sarcopenic obesity (SO) has been found to increase the risk of metabolic disorders, however, its relationship with cardiometabolic multimorbidity (CMM) remains unexplored. This study aims to investigate the potential association between SO and CMM in the middle-aged and older population.
Our study subjects were from CHARLS. SO was defined as the combination of impaired grip strength (grip strength <28 kg for men and <18 kg for women) and increased body mass index (BMI ≥25 kg/m). CMM was defined as having two or more cardiometabolic diseases, including diabetes mellitus, stroke, and heart disease. The participants were divided into four groups according to their sarcopenia and obesity status, and logistic regression analysis was used to examine the association between SO and CMM.
A total of 15,252 study subjects were included in the cross-sectional study, with an average age of 60.6 years and a male proportion of 47.4%. In the cross-sectional analysis conducted in 2015, the prevalence of CMM was highest in the SO group (9.1%), followed by the obesity (3.7%) and sarcopenia (3.5%) group. After adjustment for confounding factors, SO [OR (95%CI): 2.453 (1.742-3.455)], sarcopenia [OR (95% CI): 1.601 (1.157-2.217)], obesity [OR (95% CI): 1.446 (1.107-1.888)] were all observed to be associated with CMM, with the strongest association in the SO group. Furthermore, in the longitudinal analysis, only the SO group demonstrated a significant risk for developing CMM [OR (95% CI): 2.302 (1.239-4.228)].
SO was independently and positively associated with CMM in middle-aged and older population.
已发现肌少症性肥胖（SO）会增加代谢紊乱的风险，然而，其与心脏代谢性多重疾病（CMM）的关系仍未得到探索。本研究旨在调查中年和老年人中 SO 与 CMM 之间的潜在关联。
我们的研究对象来自 CHARLS。SO 定义为握力受损（男性<28kg，女性<18kg）和体重指数（BMI）增加（≥25kg/m）的组合。CMM 定义为患有两种或多种心脏代谢疾病，包括糖尿病、中风和心脏病。参与者根据其肌少症和肥胖状况分为四组，采用 logistic 回归分析来检验 SO 与 CMM 之间的关联。
共有 15252 名研究对象纳入横断面研究，平均年龄为 60.6 岁，男性比例为 47.4%。在 2015 年进行的横断面分析中，SO 组的 CMM 患病率最高（9.1%），其次是肥胖（3.7%）和肌少症（3.5%）组。在调整混杂因素后，SO [比值比（95%可信区间）：2.453（1.742-3.455）]、肌少症[比值比（95%可信区间）：1.601（1.157-2.217）]、肥胖[比值比（95%可信区间）：1.446（1.107-1.888）]均与 CMM 相关，SO 组关联最强。此外，在纵向分析中，只有 SO 组发生 CMM 的风险显著增加[比值比（95%可信区间）：2.302（1.239-4.228）]。
SO 与中年和老年人的 CMM 独立且呈正相关。
