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1
Hyperaldosteronism secondary to renal agenesis: An unusual cause for hypertension in pregnancy.肾发育不全继发的醛固酮增多症：妊娠期高血压的一个不寻常病因。
Pregnancy Hypertens. 2024 Dec;38:101157. doi: 10.1016/j.preghy.2024.101157. Epub 2024 Sep 7.
2
Spironolactone versus eplerenone for the treatment of idiopathic hyperaldosteronism.螺内酯与依普利酮治疗特发性醛固酮增多症的比较。
Expert Opin Pharmacother. 2008 Mar;9(4):509-15. doi: 10.1517/14656566.9.4.509.
3
Eplerenone Versus Spironolactone in Resistant Hypertension: an Efficacy and/or Cost or Just a Men's Issue?依普利酮对比螺内酯治疗抵抗性高血压：疗效和/或成本，还是仅仅是男性问题？
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Aldosterone antagonism: an emerging strategy for effective blood pressure lowering.醛固酮拮抗作用：一种新兴的有效降压策略。
Curr Hypertens Rep. 2005 Jun;7(3):186-92. doi: 10.1007/s11906-005-0008-1.
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Severe hypokalaemia in primary aldosteronism during pregnancy.妊娠期间原发性醛固酮增多症伴严重低钾血症
BMJ Case Rep. 2025 Feb 5;18(2):e262767. doi: 10.1136/bcr-2024-262767.
6
Adrenal gland inclusions in patients treated with aldosterone antagonists (Spironolactone/Eplerenone): incidence, morphology, and ultrastructural findings.接受醛固酮拮抗剂（螺内酯/依普利酮）治疗患者的肾上腺包涵体：发生率、形态及超微结构观察结果
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Diagnosing and Managing Primary Aldosteronism in Hypertensive Patients: a Case-Based Approach.高血压患者原发性醛固酮增多症的诊断与管理：基于病例的方法
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Progress in primary aldosteronism: mineralocorticoid receptor antagonists and management of primary aldosteronism in pregnancy.原发性醛固酮增多症的进展：盐皮质激素受体拮抗剂与妊娠合并原发性醛固酮增多症的管理
Eur J Endocrinol. 2015 Jan;172(1):R23-30. doi: 10.1530/EJE-14-0444. Epub 2014 Aug 27.
10
Primary aldosteronism in pregnancy.妊娠合并原发性醛固酮增多症。
Rev Endocr Metab Disord. 2023 Feb;24(1):39-48. doi: 10.1007/s11154-022-09729-6. Epub 2022 May 10.

本文引用的文献

1
Primary aldosteronism in pregnancy.妊娠合并原发性醛固酮增多症。
Rev Endocr Metab Disord. 2023 Feb;24(1):39-48. doi: 10.1007/s11154-022-09729-6. Epub 2022 May 10.
2
Eplerenone as a treatment for resistant hypertension in pregnancy.依普利酮用于治疗妊娠期顽固性高血压。
Obstet Med. 2021 Mar;14(1):35-38. doi: 10.1177/1753495X19825967. Epub 2019 Mar 24.
3
Pregnancy Outcome in Patients with Solitary Kidney.孤立肾患者的妊娠结局
J Obstet Gynaecol India. 2017 Jun;67(3):168-172. doi: 10.1007/s13224-016-0942-7. Epub 2016 Oct 17.
4
Association of Unilateral Renal Agenesis With Adverse Outcomes in Pregnancy: A Matched Cohort Study.单侧肾发育不全与妊娠不良结局的关联：一项匹配队列研究。
Am J Kidney Dis. 2017 Oct;70(4):506-511. doi: 10.1053/j.ajkd.2017.02.367. Epub 2017 Apr 7.
5
Eplerenone use in primary aldosteronism during pregnancy.依普利酮在妊娠期原发性醛固酮增多症中的应用。
Clin Case Rep. 2015 Nov 28;4(1):81-2. doi: 10.1002/ccr3.355. eCollection 2016 Jan.
6
Progress in primary aldosteronism: mineralocorticoid receptor antagonists and management of primary aldosteronism in pregnancy.原发性醛固酮增多症的进展：盐皮质激素受体拮抗剂与妊娠合并原发性醛固酮增多症的管理
Eur J Endocrinol. 2015 Jan;172(1):R23-30. doi: 10.1530/EJE-14-0444. Epub 2014 Aug 27.
7
The solitary kidney--a nephrological perspective.孤立肾——肾脏病学视角
Rom J Intern Med. 2013 Apr-Jun;51(2):80-8.
8
The effect of pregnancy on renal function: physiology and pathophysiology.
Am J Med Sci. 1992 Mar;303(3):184-205. doi: 10.1097/00000441-199203000-00011.
9
Prognosis of patients with unilateral renal agenesis.单侧肾发育不全患者的预后。
Pediatr Nephrol. 1992 Sep;6(5):412-6. doi: 10.1007/BF00873996.

肾发育不全继发的醛固酮增多症：妊娠期高血压的一个不寻常病因。

Hyperaldosteronism secondary to renal agenesis: An unusual cause for hypertension in pregnancy.

作者信息

Newbigging Nalini, Sathyendra Sowmya, Jasmine Sudha, David Liji S, Lenin Audrin, David Livingstone Jennifer, Thomas Nihal, Rajan Remya, Alexander Suceena

机构信息

Department of Medicine, Christian Medical College, Vellore, Tamil Nadu, India.

Department of Medicine, Christian Medical College, Vellore, Tamil Nadu, India; Medicine Unit 3 and Obstetric Medicine, Vellore, Tamil Nadu, India.

出版信息

Pregnancy Hypertens. 2024 Dec;38:101157. doi: 10.1016/j.preghy.2024.101157. Epub 2024 Sep 7.

DOI:10.1016/j.preghy.2024.101157
PMID:39244817
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7616660/
Abstract

Literature with regards to pregnancy related outcomes in persons with the presence of a solitary kidney of any cause is scarce. Most of the available information has been extrapolated from persons who have been renal donors. Unilateral renal agenesis affects 1 in 1500 people and can present with resistant hypertension. When a woman with a solitary kidney presents in pregnancy, it may be both a challenging diagnostic and therapeutic problem. Eplerenone, a selective aldosterone blocker has been prescribed for resistant hypertension and in the presence of pregnancy, been useful in persons with primary hyperaldosteronism and resistant hypertension due to obstructive sleep apnoea. We describe the use of Eplerenone in a patient with resistant hypertension in pregnancy, due to secondary hyperaldosteronism precipitated by renal agenesis.

摘要

关于因任何原因导致单肾的人群妊娠相关结局的文献很少。大多数现有信息是从肾捐赠者那里推断出来的。单侧肾发育不全影响1500人中的1人，可能表现为顽固性高血压。当单肾女性怀孕时，这可能是一个具有挑战性的诊断和治疗问题。依普利酮是一种选择性醛固酮阻滞剂，已被用于治疗顽固性高血压，在妊娠情况下，对原发性醛固酮增多症和阻塞性睡眠呼吸暂停引起的顽固性高血压患者有用。我们描述了依普利酮在一名因肾发育不全导致继发性醛固酮增多症而患有妊娠顽固性高血压患者中的应用。