Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Ecotoxicol Environ Saf. 2024 Oct 1;284:116998. doi: 10.1016/j.ecoenv.2024.116998. Epub 2024 Sep 7.
The associations of ambient air pollution exposure and low-grade inflammation with lung function remain uncertain. In this study, 276,289 subjects were enrolled in the UK Biobank. Individual exposure to ambient air pollution (including nitrogen dioxide [NO], nitrogen oxides [NO]), and particulate matter [PM, PM PM]) were estimated by using the land-use regression model. Forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV) were tested, and low-grade inflammation score (INFLA score) was calculated for each subject. In this cross-sectional study, the median concentrations of air pollution were 9.89 µg/m for PM, 15.98 µg/m for PM, 6.09 µg/m for PM, 25.60 µg/m for NO, and 41.46 µg/m for NO, respectively. We observed that PM, PM, PM, NO, NO was negatively associated with lung function. Besides, significant positive associations between PM exposure and low-grade inflammation were noted. Per interquartile range (IQR) increase in PM, PM, and PM was related to higher INFLA score, and the β (95 % CI) was 0.06 (0.03, 0.08), 0.03 (0.02, 0.05), and 0.03 (0.01, 0.04), respectively. Additionally, we found significant negative associations between INFLA scores and lung function. One-unit increase in INFLA score was linked with 12.41- and 11.31-ml decreases in FVC and FEV, respectively. Compared with individuals with low air pollution exposure and low INFLA scores, participants with high air pollution and high INFLA scores had the lowest FVC and FEV. Additionally, we observed that INFLA scores could modify the relationships of PM, NO and NO with FVC and FEV (P <0.05). The negative impact of air pollutants on lung function was more pronounced in subjects with high INFLA scores in comparison to those with low INFLA scores. In conclusion, we demonstrated negative associations between ambient air pollution and lung function, and the observed associations were strengthened and modified by low-grade inflammation.
暴露于环境空气污染和低度炎症与肺功能之间的关联仍然不确定。在这项研究中，共有 276289 名受试者纳入英国生物库。个体暴露于环境空气污染（包括二氧化氮[NO]、氮氧化物[NO]）和颗粒物[PM、PM、PM]），采用土地利用回归模型进行估算。对每个受试者进行用力肺活量（FVC）和 1 秒用力呼气量（FEV）测试，并计算低度炎症评分（INFLA 评分）。在这项横断面研究中，空气污染的中位数浓度分别为 PM 为 9.89μg/m、PM 为 15.98μg/m、PM 为 6.09μg/m、NO 为 25.60μg/m和 NO 为 41.46μg/m。我们观察到 PM、PM、PM、NO 和 NO 与肺功能呈负相关。此外，还发现 PM 暴露与低度炎症之间存在显著的正相关关系。PM、PM 和 PM 的 IQR 每增加一个单位，INFLA 评分就会升高，β（95%置信区间）分别为 0.06（0.03，0.08）、0.03（0.02，0.05）和 0.03（0.01，0.04）。此外，我们还发现 INFLA 评分与肺功能之间存在显著的负相关关系。INFLA 评分增加一个单位与 FVC 和 FEV 分别减少 12.41ml 和 11.31ml 有关。与低空气污染暴露和低 INFLA 评分的个体相比，高空气污染和高 INFLA 评分的个体的 FVC 和 FEV 最低。此外，我们还观察到 INFLA 评分可以改变 PM、NO 和 NO 与 FVC 和 FEV 的关系（P<0.05）。与低 INFLA 评分的个体相比，高 INFLA 评分的个体中，空气污染物对肺功能的负面影响更为明显。总之，我们证明了环境空气污染与肺功能之间存在负相关关系，而观察到的关联则因低度炎症而增强和改变。
