Non-Communicable Diseases Program, Medical Research Council/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda; Department of Medicine, Uganda Martyrs Hospital Lubaga, Kampala, Uganda.
School of Public Health, College of Health Sciences, Makerere University Kampala, Uganda.
Diabetes Metab Syndr. 2024 Aug;18(8):103115. doi: 10.1016/j.dsx.2024.103115. Epub 2024 Sep 4.
The clinical manifestation of type 2 diabetes (T2D) varies across populations. We compared the phenotypic characteristics of Black Africans and White Europeans with recently diagnosed T2D to understand the ethnic differences in the manifestation of T2D.
We searched Medline, EMBASE, CINAHL, Google Scholar, African Index Medicus, and Global Health for studies reporting information on phenotypic characteristics in Black Africans and White Europeans with recently diagnosed T2D.
A total of 28 studies were included in this systematic review (14 studies conducted on 2586 Black Africans in eight countries and 14 studies conducted on 279,621 White Europeans in nine countries). Compared with White Europeans, Black Africans had a lower pooled mean (95 % confidence interval) age (51.5 [48.5-54.4] years vs. 60.2 [57.9-62.6] years), body mass index (27.0 [24.2-29.8] kg/m vs. 31.3 [30.5-32.1] kg/m), and a higher pooled median glycated haemoglobin (9.0 [8.0-10.3]% vs. 7.1 [6.7-7.7]%). Ugandan and Tanzanian participants had lower markers of beta-cell function and insulin resistance when compared with four White European populations.
These findings provide evidence of the ethnic differences in the manifestation of T2D, underscoring the importance of understanding the underlying factors influencing these differences and formulating ethnic-specific approaches for managing and preventing T2D.
2 型糖尿病（T2D）的临床表现因人群而异。我们比较了新诊断为 T2D 的黑人和白种欧洲人的表型特征，以了解 T2D 表现方面的种族差异。
我们在 Medline、EMBASE、CINAHL、Google Scholar、African Index Medicus 和全球卫生数据库中搜索了报告黑人和白种欧洲人新诊断为 T2D 的表型特征信息的研究。
本系统评价共纳入 28 项研究（14 项研究在 8 个国家的 2586 名黑人和 14 项研究在 9 个国家的 279621 名白种欧洲人中进行）。与白种欧洲人相比，黑种人平均年龄（51.5[48.5-54.4]岁与 60.2[57.9-62.6]岁）、体重指数（27.0[24.2-29.8]kg/m与 31.3[30.5-32.1]kg/m）较低，糖化血红蛋白中位数（9.0[8.0-10.3]%与 7.1[6.7-7.7]%）较高。与四个白种欧洲人群相比，乌干达和坦桑尼亚的参与者β细胞功能和胰岛素抵抗标志物较低。
这些发现为 T2D 表现方面的种族差异提供了证据，强调了理解影响这些差异的潜在因素并制定针对特定种族的 T2D 管理和预防方法的重要性。
