Static and dynamic changes in amplitude of Low-Frequency fluctuations in patients with Self-Limited epilepsy with centrotemporal Spikes (SeLECTS): A Resting-State fMRI study.

OBJECTIVE

This study aims to explore differences in the static and dynamic amplitude of low-frequency fluctuations (sALFF and dALFF) in resting-state functional MRI (rs-fMRI) data between patients with Benign childhood epilepsy with centrotemporal spikes (SeLECTS) and healthy controls (HCs).

MATERIALS AND METHODS

We recruited 45 patient with SeLECTS and 55 HCs, employing rs-fMRI to assess brain activity. The analysis utilized a two-sample t-test for primary comparisons, supplemented by stratification and matching based on clinical and demographic characteristics to ensure comparability between groups. Post hoc analyses assessed the relationships between sALFF/dALFF alterations and clinical demographics, incorporating statistical adjustments for potential confounders and performing sensitivity analysis to test the robustness of our findings.

RESULTS

Our analysis identified significant differences in sALFF and dALFF between patient with SeLECTS and HCs. Notably, increases in sALFF and dALFF were observed in the right middle temporal gyrus and left superior temporal gyrus among patient with SeLECTS, while a decrease in dALFF was seen in the right cerebellum crus 1. Additionally, a positive correlation was found between abnormal dALFF variability in specific brain regions and various clinical and demographic factors of patient with SeLECTS, with age being one such influential factor.

CONCLUSION

This investigation provides insights into the assessment of local brain activity in SeLECTS through both static and dynamic approaches. It highlights the significance of non-invasive neuroimaging techniques in understanding the complexities of epilepsy syndromes like SeLECTS and emphasizes the need to consider a range of clinical and demographic factors in neuroimaging studies of neurological disorders.