Servergazi Denizli State Hospital, Denizli, Turkiye.
Department of Physiotherapy and Rehabilitation, Faculty of Physiotherapy and Rehabilitation, Pamukkale University, Denizli, Turkiye.
Mult Scler Relat Disord. 2024 Nov;91:105863. doi: 10.1016/j.msard.2024.105863. Epub 2024 Sep 1.
The individual experience of fatigue and fatigability in individuals with Multiple Sclerosis (MS) can vary greatly, beyond the high prevalence of fatigue in MS. Although fatigue is known as a common symptom that affects and potentially limits individuals with MS, it has recently been determined that fatigability also causes consequences that limit individuals' daily lives. The purpose of this study was to compare the associations between self-reported levels of fatigue, measured fatigability, and estimates of functional capacity in people with MS and sex- and age-matched healthy individuals.
Twenty-three individuals with Relapsing-Remitting MS (RRMS) diagnosis and 23 age- and sex-matched healthy individuals were included in the study. To examine the fatigability level Dynamic and Static Fatigue Index were used for gross and pinch-grip, and manual dexterity and functionality levels the Scale for the Assessment and Rating of Ataxia (SARA), Nine Hole Peg Test (NHPT), and Dexterity Questionnaire-24 (DextQ-24) were used. While the Fatigue Severity Scale (FSS) and Fatigue Impact Scale (FIS) were used to examine self-reported fatigue, the Beck Depression Inventory (BDI) was used to assess emotional status.
There was no difference between RRMS and healthy individuals in terms of fatigability levels (p > 0.05). While the relationship between Static and Dynamic Fatigue Index gross grip fatigability and FSS and FIS was not found to be statistically significant, the relationship between non-dominant side pinch grip Static Fatigue Index and FSS and FIS was significant. In addition, the relationship between the non-dominant side gross grip Static Fatigue Index and the DextQ-24 dressing and daily activities subsections, and the dominant side pinch grip Dynamic Fatigue Index and the television/compact disk/digital video disk subsection of DextQ-24 was significant (p < 0.05).
Fatigability was related to daily life upper limb use for gross grip and self-reported fatigue for pinch grip in individuals with RRMS. It was concluded that future studies focusing on hand fatigability could also consider manual dexterity and self-reported fatigue in individuals with MS from the early-stage. Clarifying the relationship of between fatigability and self-reported fatigue to functioning will allow clinicians to plan more appropriate and directed treatment approaches for individuals with RRMS.
ClinicalTrials.gov NCT05880745.
多发性硬化症（MS）患者的个体疲劳和易疲劳感差异很大，远超 MS 患者中普遍存在的疲劳现象。尽管疲劳已被确定为影响并可能限制 MS 患者的常见症状，但最近发现易疲劳也会导致限制患者日常生活的后果。本研究旨在比较 MS 患者与性别和年龄匹配的健康个体之间自我报告的疲劳水平、测量的疲劳度以及功能能力的估计值之间的关联。
本研究纳入了 23 名复发性缓解型 MS（RRMS）患者和 23 名年龄和性别匹配的健康个体。为了评估疲劳程度，使用动态和静态疲劳指数评估总体和捏力握力，使用共济失调评估和评定量表（SARA）、九孔钉测试（NHPT）和灵巧度问卷-24（DextQ-24）评估手的灵巧度和功能。使用疲劳严重程度量表（FSS）和疲劳影响量表（FIS）评估自我报告的疲劳，使用贝克抑郁量表（BDI）评估情绪状态。
RRMS 患者和健康个体之间的疲劳度无差异（p＞0.05）。虽然静态和动态疲劳指数总体握力疲劳度与 FSS 和 FIS 之间的关系没有统计学意义，但非优势侧捏力握静态疲劳度与 FSS 和 FIS 之间的关系有统计学意义。此外，非优势侧总体握力静态疲劳指数与 DextQ-24 穿衣和日常活动子项，以及优势侧捏力握动态疲劳指数与 DextQ-24 的电视/光盘/数字视频光盘子项之间的关系有统计学意义（p＜0.05）。
RRMS 患者的总体握力疲劳度与日常生活上肢使用有关，捏力握疲劳度与自我报告的疲劳有关。结论是，未来的研究如果关注手部疲劳度，也可以考虑在 MS 患者的早期阶段评估手的灵巧度和自我报告的疲劳度。阐明疲劳度与自我报告的疲劳度与功能之间的关系，将使临床医生能够为 RRMS 患者制定更合适和有针对性的治疗方法。
ClinicalTrials.gov NCT05880745。
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