糖尿病足前足骨髓炎且残留感染骨培养呈阳性时，截肢后抗生素治疗三周与六周的对比研究
Three versus six weeks of post-amputation antibiotic therapy in diabetic forefoot osteomyelitis with positive culture for residual infected bone.
作者信息
Petithomme-Nanrocki Maïwenn, Slitine Ines, Diallo Saidou, Crouzet Martine, Mostaert Malorie, Moysset Pascale, Ly Thanh Quang Sang, Hentzien Maxime, Francois Maud, Bani-Sadr Firouzé
机构信息
Department of Internal Medicine and Infectious Diseases, Reims Teaching Hospitals, Reims, France.
Department of Rheumatology, Reims Teaching Hospitals, Reims, France.
出版信息
Infect Dis Now. 2024 Oct;54(7):104975. doi: 10.1016/j.idnow.2024.104975. Epub 2024 Sep 6.
OBJECTIVES
In 2021 in our university hospital, it was decided in a multidisciplinary consultation meeting on osteoarticular infection in patients with diabetic foot to reduce the duration of post-amputation antibiotic therapy from six to three weeks in patients with diabetic forefoot osteomyelitis and residual bone infection. This study aimed to compare clinical outcomes in this group of patients, before vs after the change in practice introduced in 2021.
METHODS
In this before-after study, we included all cases reported between January 2016 and August 2023 in the University Hospital of Reims.
RESULTS
We included 113 patients; between 2016 and 2020, 56 (49.5 %) received six weeks of post-amputation antibiotic therapy, and between 2021 and 2023, 57 (50.5 %) received three weeks of therapy. Over six months of follow-up, overall cure rate was 95 %. Treatment failure did not differ between groups.
CONCLUSION
Three weeks of post-amputation antibiotic therapy in diabetic patients with forefoot osteomyelitis and residual bone infection is effective.
目的
2021年，在我校附属医院召开的糖尿病足患者骨关节炎感染多学科会诊会议上，决定将糖尿病足前足骨髓炎和残留骨感染患者截肢术后抗生素治疗时长从六周减至三周。本研究旨在比较2021年实践改变前后该组患者的临床结局。
方法
在这项前后对照研究中，我们纳入了2016年1月至2023年8月在兰斯大学医院报告的所有病例。
结果
我们纳入了113例患者；2016年至2020年期间，56例（49.5%）接受了六周的截肢术后抗生素治疗，2021年至2023年期间，57例（50.5%）接受了三周的治疗。在超过六个月的随访中，总体治愈率为95%。两组之间的治疗失败情况没有差异。
结论
糖尿病足前足骨髓炎和残留骨感染患者截肢术后三周的抗生素治疗是有效的。
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