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静脉注射唑来膦酸对肩袖修复术后老年骨质疏松症患者的疗效：一项回顾性研究。

The effectiveness of intravenous zoledronic acid in elderly patients with osteoporosis after rotator cuff repair: a retrospective study.

机构信息

Centre of Orthopaedics, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, 710004, Shaanxi Province, People's Republic of China.

Department of Orthopaedics, Xi'an No. 3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, 710004, Shaanxi Province, People's Republic of China.

出版信息

Sci Rep. 2024 Sep 8;14(1):20891. doi: 10.1038/s41598-024-68246-5.

DOI:10.1038/s41598-024-68246-5
PMID:39245701
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11381515/
Abstract

The aim of this study was to investigate the effect of zoledronic acid (ZA) on postoperative healing and functional rehabilitation in osteoporotic patients with rotator cuff (RC) injury. 96 Patients were divided into three groups according to bone mineral density and ZA use (Group A: normal BMD; Group B: osteoporosis and intravenous ZA use; Group C: osteoporosis, without ZA use). Radiologic, functional and Serological outcomes were evaluated 6 months after surgery. The functional scores in all groups exhibited significant improvement 6 months after surgery. Inter-group comparison showed that Constant Shoulder joint function Score (CSS) of group A not significantly differing from that of group B, the other indicators were significantly better than those of group B and C. There were no significant differences in shoulder forward flexion, abductive Range of Motion between group B and C. Other indicators of group B were significantly improved compared to group C. The retear rate in group C (30.3%, 10/33) was higher than group A (6.1%, 2/33) and group B (13.3%, 4/30). In conclusion, the application of ZA can significantly reduce the rate of RC retear in elderly patients with osteoporosis after surgery, which is significant for postoperative shoulder joint functional rehabilitation.

摘要

本研究旨在探讨唑来膦酸（ZA）对骨质疏松合并肩袖损伤患者术后愈合和功能康复的影响。96 例患者根据骨密度和 ZA 使用情况分为三组（A 组：正常骨密度；B 组：骨质疏松症和静脉 ZA 使用；C 组：骨质疏松症，未使用 ZA）。术后 6 个月评估影像学、功能和血清学结果。所有组的功能评分在术后 6 个月均有显著改善。组间比较显示，A 组的 Constant 肩关节功能评分（CSS）与 B 组无显著差异，其他指标明显优于 B 组和 C 组。B 组和 C 组间肩前屈和外展活动度无显著差异。与 C 组相比，B 组的其他指标明显改善。C 组（30.3%，10/33）的再撕裂率高于 A 组（6.1%，2/33）和 B 组（13.3%，4/30）。综上所述，ZA 的应用可显著降低老年骨质疏松症患者术后肩袖再撕裂的发生率，对术后肩关节功能康复有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/193b/11381515/c0eb6946c4a3/41598_2024_68246_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/193b/11381515/3a88bdd4565d/41598_2024_68246_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/193b/11381515/e17d3c32deb6/41598_2024_68246_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/193b/11381515/16b39ef38c8c/41598_2024_68246_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/193b/11381515/c0eb6946c4a3/41598_2024_68246_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/193b/11381515/3a88bdd4565d/41598_2024_68246_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/193b/11381515/e17d3c32deb6/41598_2024_68246_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/193b/11381515/16b39ef38c8c/41598_2024_68246_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/193b/11381515/c0eb6946c4a3/41598_2024_68246_Fig4_HTML.jpg

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