Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
Department of Occupational Therapy and Physiotherapy, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
Physiol Rep. 2024 Sep;12(17):e16184. doi: 10.14814/phy2.16184.
After COVID-19 long term respiratory symptoms and reduced lung function including maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) have been reported. However, no studies have looked at MIP and MEP in all disease groups and the reference materials collection methods differ substantially. We aimed to determine MIP and MEP in individuals after COVID-19 infection with different disease severity using reference material of healthy control group obtained using the same standardized method. Patients with COVID-19 were included March 2020-March 2021 at Rigshospitalet, Denmark. MIP and MEP were measured using microRPM. Predicted MIP and MEP were calculated using reference material obtained from 298 healthy adults aged 18-97 years using the same method. In SECURe, 145 participants were measured median 5 months after COVID-19 diagnosis and of these 16% had reduced MIP and/or MEP. There was reduced spirometry and total lung capacity, but not reduced diffusion capacity in those with abnormal MIP and/or MEP compared with normal MIP and MEP. Of those with reduced MIP and/or MEP at 5 months, 80% still had reduced MIP and/or MEP at 12 months follow-up. In conclusion, few have reduced MIP and/or MEP 5 months after COVID-19 and little improvement was seen over time.
在 COVID-19 之后，已经报道了长期的呼吸症状和肺功能下降，包括最大吸气压力（MIP）和最大呼气压力（MEP）。然而，尚无研究观察到所有疾病组中的 MIP 和 MEP，并且参考材料的收集方法有很大差异。我们旨在使用相同标准化方法获得的健康对照组参考材料，确定 COVID-19 感染后不同疾病严重程度个体的 MIP 和 MEP。2020 年 3 月至 2021 年 3 月在丹麦 Rigshospitalet 纳入 COVID-19 患者。使用 microRPM 测量 MIP 和 MEP。使用相同方法获得的 298 名年龄在 18-97 岁的健康成年人的参考材料计算预测的 MIP 和 MEP。在 SECURe 中，145 名参与者在 COVID-19 诊断后中位 5 个月进行了测量，其中 16%的人 MIP 和/或 MEP 降低。与 MIP 和 MEP 正常的患者相比，MIP 和/或 MEP 异常的患者的肺活量和肺总量下降，但弥散能力正常。在 5 个月时 MIP 和/或 MEP 降低的患者中，80%在 12 个月随访时仍存在 MIP 和/或 MEP 降低。总之，COVID-19 后 5 个月时，MIP 和/或 MEP 降低的患者很少，并且随着时间的推移，改善甚微。
