Department of Medicine and Surgery, Università degli Studi di Enna "Kore", Enna, Italy.
Division of Cardiology, Ospedale Umberto I, ASP 4 di Enna, Enna, Italy.
Expert Rev Med Devices. 2024 Oct;21(10):915-925. doi: 10.1080/17434440.2024.2401492. Epub 2024 Sep 13.
Patients with severe aortic stenosis referred for transcatheter aortic valve implantation (TAVI) often present with concomitant coronary artery disease (CAD). The management of CAD in these patients remains a topic of debate, encompassing the evaluation and timing of percutaneous coronary intervention (PCI).
This review article aims to offer an overview of the role of coronary revascularization in TAVI patients, highlighting the advantages and disadvantages of different strategies: PCI before, concomitant with, and after TAVI. Considering that TAVI indications are expanding and patients with low surgical risk are now being referred for TAVI, the rate of PCI among patients undergoing TAVI is expected to increase. Historically, PCI was performed before TAVI. However, there is now a growing trend to defer PCI until after TAVI.
It is plausible that in the future, there will be an increase in PCI after TAVI due to several factors: first, multiple studies have shown the safety of TAVI even in patients with severe untreated CAD; second, improvements in TAVI device implantation techniques, such as commissural alignment and patient-specific device selection, have improved access to the coronary arteries post-TAVI.
接受经导管主动脉瓣植入术(TAVI)治疗的严重主动脉瓣狭窄患者常伴有冠状动脉疾病(CAD)。这些患者 CAD 的管理仍然是一个有争议的话题,包括经皮冠状动脉介入治疗(PCI)的评估和时机。
本文旨在概述冠状动脉血运重建术在 TAVI 患者中的作用,强调不同策略的优缺点:TAVI 前、同时和之后的 PCI。鉴于 TAVI 适应证不断扩大,低手术风险的患者现在也被推荐接受 TAVI,接受 TAVI 的患者中 PCI 的比例预计会增加。历史上,PCI 是在 TAVI 之前进行的。然而,现在越来越倾向于将 PCI 推迟到 TAVI 之后。
由于多种因素,未来 TAVI 后 PCI 的数量可能会增加:首先,多项研究表明,即使在未经治疗的严重 CAD 患者中,TAVI 也是安全的;其次,TAVI 器械植入技术的改进,如交界对准和患者特异性器械选择,改善了 TAVI 后的冠状动脉通路。