Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai, the People's Republic of China.
Am J Physiol Cell Physiol. 2024 Nov 1;327(5):C1192-C1201. doi: 10.1152/ajpcell.00288.2024. Epub 2024 Sep 9.
Cell migration is a fundamental and functional cellular process, influenced by a complex microenvironment consisting of different cells and extracellular matrix. Recent research has highlighted that, besides biochemical cues from the microenvironment, physical cues can also greatly alter cellular behavior. However, due to the complexity of the microenvironment, little is known about how the physical interactions between migrating cells and surrounding microenvironment instructs cell movement. Here, we explore various examples of three-dimensional microenvironment reconstruction models in vitro and describe how the physical interplay between migrating cells and the neighboring microenvironment controls cell behavior. Understanding this mechanical cooperation will provide key insights into organ development, regeneration, and tumor metastasis.
细胞迁移是一种基本的、功能性的细胞过程，受到由不同细胞和细胞外基质组成的复杂微环境的影响。最近的研究强调，除了微环境中的生化信号外，物理信号也可以极大地改变细胞的行为。然而，由于微环境的复杂性，人们对细胞迁移和周围微环境之间的物理相互作用如何指导细胞运动知之甚少。在这里，我们探讨了体外重建三维微环境的各种范例，并描述了迁移细胞与相邻微环境之间的物理相互作用如何控制细胞行为。理解这种机械协同作用将为器官发育、再生和肿瘤转移提供关键的见解。
