Effect of neonatal sympathectomy by 6-hydroxydopamine on renal hemodynamic parameters in adult rats.

Newborn rats were sympathectomized with 6-hydroxydopamine (6-OHDA) (10 mg/100 g b.w., once daily on the first 4 postnatal days). Hemodynamic parameters were determined at the 55th d of life. In comparison to non-sympathectomized control rats the blood pressure and total peripheral resistance of 6-OHDA treated animals were significantly diminished whereas the cardiac output was enhanced. In sympathectomized rats the resistance values of the whole kidney as well as of the cortex and outer medulla were lower than in control animals. No redistribution of renal blood flow was detectable. The results show a long lasting effect of neonatal denervation by 6-OHDA at least up to the 55th d of life.