Appenroth D, Hably C, Bartha J, Bräunlich H
Exp Pathol. 1985;27(3):185-8. doi: 10.1016/s0232-1513(85)80041-4.
Newborn rats were sympathectomized with 6-hydroxydopamine (6-OHDA) (10 mg/100 g b.w., once daily on the first 4 postnatal days). Hemodynamic parameters were determined at the 55th d of life. In comparison to non-sympathectomized control rats the blood pressure and total peripheral resistance of 6-OHDA treated animals were significantly diminished whereas the cardiac output was enhanced. In sympathectomized rats the resistance values of the whole kidney as well as of the cortex and outer medulla were lower than in control animals. No redistribution of renal blood flow was detectable. The results show a long lasting effect of neonatal denervation by 6-OHDA at least up to the 55th d of life.
新生大鼠在出生后的前4天每天用6-羟基多巴胺（6-OHDA）（10mg/100g体重）进行交感神经切除术。在出生后第55天测定血流动力学参数。与未进行交感神经切除术的对照大鼠相比，经6-OHDA处理的动物的血压和总外周阻力显著降低，而心输出量增加。在交感神经切除的大鼠中，整个肾脏以及皮质和外髓质的阻力值均低于对照动物。未检测到肾血流的重新分布。结果表明，6-OHDA对新生大鼠去神经支配具有至少持续到出生后第55天的长期影响。
