碰撞瘤由慢性淋巴细胞白血病和黏液乳头型室管膜瘤组成。
Collision tumor comprised of chronic lymphocytic leukemia and myxopapillary ependymoma.
作者信息
Aly Ahmed, Nagaraju Santhosh, Price Rupert
机构信息
Department of Neurosurgery, University Hospitals North Midlands NHS Trust, Stoke-on-Trent, United Kingdom.
Department of Pathology, University Hospitals Birmingham NHS Trust, Birmingham QE Hospital, Birmingham, United Kingdom.
出版信息
Surg Neurol Int. 2024 Aug 9;15:282. doi: 10.25259/SNI_658_2023. eCollection 2024.
BACKGROUND
Collision tumors involving the co-occurrence of two morphologically and genomically distinct neoplasms in the same anatomical site are exceptionally rare in the central nervous system (CNS).
CASE DESCRIPTION
We report a unique case of a CNS collision tumor comprising chronic lymphocytic leukemia and myxopapillary ependymoma in a 77-year-old male with acute neurological decline. Presumed to represent leukemic infiltration, urgent laminectomy was pursued for tissue diagnosis and spinal cord decompression, revealing the unexpected ependymal component.
CONCLUSION
This case highlights the diagnostic and therapeutic challenges inherent to managing collision CNS tumors, particularly when one neoplasm is hematological.
背景
在同一解剖部位同时出现两种形态和基因组不同的肿瘤的碰撞瘤在中枢神经系统（CNS）中极为罕见。
病例描述
我们报告了一例独特的中枢神经系统碰撞瘤病例，该病例发生在一名77岁急性神经功能衰退的男性身上，肿瘤由慢性淋巴细胞白血病和黏液乳头型室管膜瘤组成。由于推测为白血病浸润，遂进行紧急椎板切除术以进行组织诊断和脊髓减压，结果意外发现了室管膜成分。
结论
该病例突出了管理中枢神经系统碰撞瘤所固有的诊断和治疗挑战，尤其是当其中一种肿瘤为血液系统肿瘤时。
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