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松果体区碰撞瘤

Pineal region collision tumor.

作者信息

Marčinković Petar, Blažević Andrea, Muller Danko, Šturlić Martina, Raguž Marina, Orešković Darko, Chudy Darko, Marinović Tonko

机构信息

Department of Neurosurgery, University Hospital Dubrava, Avenija Gojka Šuška 6, 10000 Zagreb, Croatia.

Department of Pathology and Cytology, University Hospital Dubrava, Avenija Gojka Šuška 6, 10000 Zagreb, Croatia.

出版信息

J Surg Case Rep. 2025 Jun 18;2025(6):rjaf432. doi: 10.1093/jscr/rjaf432. eCollection 2025 Jun.

DOI:10.1093/jscr/rjaf432
PMID:40585941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12203662/
Abstract

Collision tumors are exceptionally rare neoplasms characterized by simultaneous presence of two histologically distinct primary brain tumors in the same anatomic location. Their composition can pose a significant therapeutic challenge. Herein, we present a case of a successfully resected pineal region collision tumor composed of a pineocytoma and a pilocytic astrocytoma (PA). A 19-year-old female was admitted with obstructive hydrocephalus due to a pineal gland cyst and underwent surgical excision. Histopathological analysis confirmed a collision tumor comprising pineocytoma and PA. Collision tumors composed of both pineocytoma and PA are extremely rare, with limited cases reported. Their histological architecture presents a diagnostic challenge, requiring meticulous evaluation even by experienced neuropathologists. Given the rarity of such cases, increased awareness of these tumors will facilitate the development of standardized diagnostic criteria and treatment protocols. Multidisciplinary collaboration is essential for optimizing therapeutic strategies tailored to the specific histological composition of collision tumors.

摘要

碰撞瘤是一种极为罕见的肿瘤，其特征是在同一解剖位置同时存在两种组织学上不同的原发性脑肿瘤。它们的组成可能带来重大的治疗挑战。在此，我们报告一例成功切除的由松果体细胞瘤和毛细胞型星形细胞瘤（PA）组成的松果体区碰撞瘤病例。一名19岁女性因松果体囊肿导致梗阻性脑积水入院并接受了手术切除。组织病理学分析证实为包含松果体细胞瘤和PA的碰撞瘤。由松果体细胞瘤和PA组成的碰撞瘤极其罕见，报道的病例有限。它们的组织学结构带来了诊断挑战，即使是经验丰富的神经病理学家也需要仔细评估。鉴于此类病例的罕见性，提高对这些肿瘤的认识将有助于制定标准化的诊断标准和治疗方案。多学科协作对于优化针对碰撞瘤特定组织学组成的治疗策略至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ba3/12203662/1b2759dc1a14/rjaf432f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ba3/12203662/95df5b7ed438/rjaf432f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ba3/12203662/559b2e054a07/rjaf432f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ba3/12203662/8cb3eff59486/rjaf432f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ba3/12203662/1b2759dc1a14/rjaf432f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ba3/12203662/95df5b7ed438/rjaf432f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ba3/12203662/559b2e054a07/rjaf432f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ba3/12203662/8cb3eff59486/rjaf432f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ba3/12203662/1b2759dc1a14/rjaf432f4.jpg

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本文引用的文献

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Collision tumor comprised of chronic lymphocytic leukemia and myxopapillary ependymoma.碰撞瘤由慢性淋巴细胞白血病和黏液乳头型室管膜瘤组成。
Surg Neurol Int. 2024 Aug 9;15:282. doi: 10.25259/SNI_658_2023. eCollection 2024.
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Sentinel report of uniquely paired collision tumors: glioblastoma multiforme and coexistent intraventricular subependymoma. Illustrative case.独特配对碰撞肿瘤的哨兵报告：多形性胶质母细胞瘤与并存的脑室内室管膜下瘤。病例说明。
J Neurosurg Case Lessons. 2024 Mar 11;7(11). doi: 10.3171/CASE2423.
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Pilocytic astrocytoma: The paradigmatic entity in low‑grade gliomas (Review).
毛细胞型星形细胞瘤：低级别胶质瘤中的典型实体（综述）
Oncol Lett. 2024 Feb 8;27(4):146. doi: 10.3892/ol.2024.14279. eCollection 2024 Apr.
4
Is simultaneous occurrence of meningioma and glioblastoma a mere coincidence?脑膜瘤和胶质母细胞瘤同时发生仅仅是巧合吗？
Clin Neurol Neurosurg. 2024 Jan;236:108099. doi: 10.1016/j.clineuro.2023.108099. Epub 2023 Dec 27.
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Case report: Two unique cases of co-existing primary brain tumors of glial origin in opposite hemispheres.病例报告：两例独特的病例，双侧大脑半球同时存在胶质源性原发性脑肿瘤。
Front Oncol. 2022 Dec 7;12:1018840. doi: 10.3389/fonc.2022.1018840. eCollection 2022.
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Radiotherapy After Endoscopic Biopsy in an Adult with Pineocytoma, the Rare Brain Tumor in an Adult: A Case Report and Literature Review.成人松果体细胞瘤（一种成人罕见脑肿瘤）内镜活检后的放射治疗：病例报告及文献综述
Int Med Case Rep J. 2022 Jun 18;15:307-311. doi: 10.2147/IMCRJ.S367293. eCollection 2022.
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Collision brain tumor with atypical meningioma and glioblastoma: Case report.碰撞性脑肿瘤合并非典型脑膜瘤和胶质母细胞瘤：病例报告
Int J Surg Case Rep. 2022 May;94:107137. doi: 10.1016/j.ijscr.2022.107137. Epub 2022 May 4.
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The 2021 WHO Classification of Tumors of the Central Nervous System: a summary.2021 年世卫组织中枢神经系统肿瘤分类：概述。
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