腰椎管狭窄症患者的脑脊液蛋白浓度
Cerebrospinal fluid protein concentration in patients with lumbar spinal stenosis.
作者信息
Yamahata Hitoshi, Ijiri Kosei, Tanabe Fumito, Murasumi Kyoichi, Nagano Yushi, Makino Ryutaro, Higa Nayuta, Hanaya Ryosuke
机构信息
Department of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kirishima, Kagoshima, Japan.
Department of Orthopaedics, Kirishima Orthopaedics, Kirishima, Kagoshima, Japan.
出版信息
Surg Neurol Int. 2024 Aug 23;15:303. doi: 10.25259/SNI_610_2024. eCollection 2024.
BACKGROUND
In this study, we examined the impact and degree of lumbar stenosis on cerebrospinal fluid (CSF) protein concentration.
METHODS
In this retrospective study, we analyzed protein concentrations in CSF samples of 61 patients with lumbar spinal stenosis (LSS) obtained during pre-operative myelography. Patients were divided into two groups: those showing no block to contrast (Group A) versus those showing medium block to contrast below the lumbar puncture level (Group B).
RESULTS
The CSF protein concentration in Group B (104.3 ± 59 g/dL) patients with medium block was significantly greater than that in Group A (65.1 ± 33 g/dL) patients without medium block.
CONCLUSION
A higher average CSF protein concentration was seen in Group B patients with significant lumbar stenosis versus Group A patients without significant lumbar stenosis. Theoretically, damage to the cauda equina in patients with LSS may cause these elevated CSF protein levels.
背景
在本研究中，我们研究了腰椎管狭窄对脑脊液（CSF）蛋白浓度的影响及程度。
方法
在这项回顾性研究中，我们分析了61例腰椎管狭窄症（LSS）患者术前脊髓造影时获取的脑脊液样本中的蛋白浓度。患者分为两组：造影剂无阻滞的患者（A组）和腰椎穿刺水平以下造影剂中度阻滞的患者（B组）。
结果
B组中度阻滞患者的脑脊液蛋白浓度（104.3±59 g/dL）显著高于A组无中度阻滞患者（65.1±33 g/dL）。
结论
与无明显腰椎管狭窄的A组患者相比，有明显腰椎管狭窄的B组患者脑脊液蛋白平均浓度更高。理论上，LSS患者马尾神经损伤可能导致这些脑脊液蛋白水平升高。
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