Raja Soh Raja Siti Syazana, Hapidin Hermizi, Kasiram Mohamad Zahid
Department of Biomedical Science, Kulliyah of Allied Health Sciences, International Islamic University Malaysia (IIUM), Pahang, Malaysia.
Biomedicine Programme, School of Health Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.
Malays J Med Sci. 2024 Aug;31(4):63-77. doi: 10.21315/mjms2024.31.4.5. Epub 2024 Aug 27.
L., better known by its popular cultivar cantaloupe, is an economically significant crop in the Cucurbitaceae family. Melon peel and seeds have shown medicinal potential due to their numerous biological qualities, including anti-inflammatory, anti-cancer, antibacterial, hepatoprotective and immunomodulatory effects to treat cardiovascular disease, diabetes and oedema. This scoping review aims to broaden the research scope on the cancer-fighting abilities of melon extract and its half maximal inhibitory concentration (IC). Three databases which are Scopus, ScienceDirect and PubMed were used to locate relevant publications utilising the keywords 'melon', '', 'inhibitory activity', 'cancer' and 'anti-cancer'. The Preferred Reporting Items for Systematic and Meta-analyses extension for Scoping Review (PRISMA-ScR) framework was used in conducting this study. Out of 904 articles, 14 articles met the inclusion criteria and were used in this analysis. These articles were published in English between 2000 and 2023 with full text accessibility, specifically addressed the fruit cantaloupe ( L.) or melon and reported on any type of cancer. extract showed promising anti-cancer action in both in vitro and in vivo investigations on eight different cancer types: cervical, colon, prostate, leukaemia, multiple myeloma, breast, hepatoma and ovarian cancer. A thorough analysis shows that some of the IC values were significantly low, especially in cases of colon and prostate cancer, indicating a significant anti-cancer effect. The substantial anti-cancer benefits of fruit extracts point to the necessity for additional investigation into their potential for cancer therapy on each form of cancer.
甜瓜（学名：Cucumis melo L.，其广受欢迎的栽培品种哈密瓜更为人熟知）是葫芦科一种具有重要经济意义的作物。甜瓜皮和种子因其多种生物学特性，包括抗炎、抗癌、抗菌、保肝和免疫调节作用，在治疗心血管疾病、糖尿病和水肿方面显示出药用潜力。本综述旨在扩大对甜瓜提取物抗癌能力及其半数最大抑制浓度（IC）的研究范围。使用Scopus、ScienceDirect和PubMed这三个数据库，通过关键词“甜瓜”、“抑制活性”、“癌症”和“抗癌”来查找相关出版物。本研究采用了系统评价和Meta分析扩展版的范围综述首选报告项目（PRISMA-ScR）框架。在904篇文章中，有14篇文章符合纳入标准并用于本分析。这些文章于2000年至2023年期间以英文发表，具有全文获取权限，特别涉及水果甜瓜（Cucumis melo L.）或甜瓜，并报告了任何类型的癌症。甜瓜提取物在对八种不同癌症类型（宫颈癌、结肠癌、前列腺癌、白血病、多发性骨髓瘤、乳腺癌、肝癌和卵巢癌）的体外和体内研究中均显示出有前景的抗癌作用。深入分析表明，一些IC值显著较低，尤其是在结肠癌和前列腺癌的情况下，表明具有显著的抗癌效果。甜瓜果实提取物的显著抗癌益处表明有必要进一步研究其对每种癌症类型的癌症治疗潜力。
