• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

可生物降解的两性离子聚合物作为聚乙二醇的替代物用于药物递送

Biodegradable Zwitterionic Polymers as PEG Alternatives for Drug Delivery.

作者信息

Zhang Ziwen, Sun Haotian, Giannino Justin, Wu Yun, Cheng Chong

机构信息

Department of Chemical and Biological Engineering, University at Buffalo, the State University of New York, Buffalo, NY 14260.

Department of Biomedical Engineering, University at Buffalo, the State University of New York, Buffalo, NY 14260.

出版信息

J Polym Sci (2020). 2024 May 15;62(10):2231-2250. doi: 10.1002/pol.20230916. Epub 2024 Mar 5.

DOI:10.1002/pol.20230916
PMID:39247254
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11376432/
Abstract

Poly(ethylene glycol) (PEG) is a highly biocompatible and water-soluble polymer that is widely utilized for biomedical applications. Unfortunately, the immunogenicity and antigenicity of PEG severely restrict the biomedical efficacy of pegylated therapeutics. As emerging PEG alternatives, biodegradable zwitterionic polymers (ZPs) have attracted significant interest in recent years. Biodegradable ZPs generally are not only water-soluble and immunologically inert, but also possess a range of favorable biomedically relevant properties, without causing long-term side effects for biomedical applications. This review presents a systematic overview of recent studies on biodegradable ZPs. Their structural designs and synthetic strategies by integrating biodegradable base polymers with zwitterions are addressed. Their applications in the delivery of small molecule drugs (as mono-drugs or multi-drugs) and proteins are highlighted.

摘要

聚乙二醇（PEG）是一种具有高度生物相容性且水溶性的聚合物，广泛应用于生物医学领域。不幸的是，PEG的免疫原性和抗原性严重限制了聚乙二醇化治疗药物的生物医学疗效。作为新兴的PEG替代物，可生物降解的两性离子聚合物（ZPs）近年来引起了广泛关注。可生物降解的ZPs通常不仅具有水溶性和免疫惰性，还具有一系列有利于生物医学应用的特性，且不会对生物医学应用造成长期副作用。本综述对可生物降解ZPs的近期研究进行了系统概述。阐述了通过将可生物降解的基础聚合物与两性离子相结合的结构设计和合成策略。重点介绍了它们在小分子药物（作为单一药物或多种药物）和蛋白质递送方面的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/4d6a24d22b9f/nihms-1964986-f0021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/613c28fed546/nihms-1964986-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/d71e3277ac67/nihms-1964986-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/fbe0da002e58/nihms-1964986-f0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/7883f8259f75/nihms-1964986-f0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/91dc00f333b3/nihms-1964986-f0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/48d371253ba1/nihms-1964986-f0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/414dbefb18fb/nihms-1964986-f0013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/65815e90a699/nihms-1964986-f0014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/389c5d9f0143/nihms-1964986-f0015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/177e77880002/nihms-1964986-f0016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/297abe0e7ab9/nihms-1964986-f0017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/2ce0cb92e516/nihms-1964986-f0018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/eaa2dc839ce7/nihms-1964986-f0019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/3c9416002518/nihms-1964986-f0020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/4d6a24d22b9f/nihms-1964986-f0021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/613c28fed546/nihms-1964986-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/d71e3277ac67/nihms-1964986-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/fbe0da002e58/nihms-1964986-f0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/7883f8259f75/nihms-1964986-f0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/91dc00f333b3/nihms-1964986-f0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/48d371253ba1/nihms-1964986-f0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/414dbefb18fb/nihms-1964986-f0013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/65815e90a699/nihms-1964986-f0014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/389c5d9f0143/nihms-1964986-f0015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/177e77880002/nihms-1964986-f0016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/297abe0e7ab9/nihms-1964986-f0017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/2ce0cb92e516/nihms-1964986-f0018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/eaa2dc839ce7/nihms-1964986-f0019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/3c9416002518/nihms-1964986-f0020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/736e/11376432/4d6a24d22b9f/nihms-1964986-f0021.jpg

相似文献

1
Biodegradable Zwitterionic Polymers as PEG Alternatives for Drug Delivery.可生物降解的两性离子聚合物作为聚乙二醇的替代物用于药物递送
J Polym Sci (2020). 2024 May 15;62(10):2231-2250. doi: 10.1002/pol.20230916. Epub 2024 Mar 5.
2
Zwitterionic Polymers for Biomedical Applications: Antimicrobial and Antifouling Strategies toward Implantable Medical Devices and Drug Delivery.两性离子聚合物在生物医学中的应用：用于植入式医疗器械和药物输送的抗菌和抗污策略。
Langmuir. 2024 Nov 5;40(44):23125-23145. doi: 10.1021/acs.langmuir.4c02664. Epub 2024 Oct 25.
3
The Importance of Poly(ethylene glycol) Alternatives for Overcoming PEG Immunogenicity in Drug Delivery and Bioconjugation.聚乙二醇替代物在克服药物递送和生物偶联中聚乙二醇免疫原性方面的重要性。
Polymers (Basel). 2020 Feb 2;12(2):298. doi: 10.3390/polym12020298.
4
Integrated antimicrobial and nonfouling zwitterionic polymers.整合抗菌与抗污两性离子聚合物。
Angew Chem Int Ed Engl. 2014 Feb 10;53(7):1746-54. doi: 10.1002/anie.201304060. Epub 2014 Jan 20.
5
Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives.聚乙二醇在药物传递中的应用：优缺点及潜在替代品。
Angew Chem Int Ed Engl. 2010 Aug 23;49(36):6288-308. doi: 10.1002/anie.200902672.
6
Critical Review of Biodegradable and Bioactive Polymer Composites for Bone Tissue Engineering and Drug Delivery Applications.用于骨组织工程和药物递送应用的可生物降解和生物活性聚合物复合材料的批判性综述
Polymers (Basel). 2021 Aug 6;13(16):2623. doi: 10.3390/polym13162623.
7
Biodegradable zwitterionic sulfobetaine polymer and its conjugate with paclitaxel for sustained drug delivery.可生物降解的两性离子磺基甜菜碱聚合物及其与紫杉醇的缀合物用于药物持续递送。
Acta Biomater. 2017 Dec;64:290-300. doi: 10.1016/j.actbio.2017.10.016. Epub 2017 Oct 10.
8
Emerging uses of PLA-PEG copolymer in cancer drug delivery.聚乳酸-聚乙二醇共聚物在癌症药物递送中的新兴应用。
3 Biotech. 2022 Feb;12(2):41. doi: 10.1007/s13205-021-03105-y. Epub 2022 Jan 10.
9
Zwitterionic Polymer: A New Paradigm for Protein Conjugation beyond PEG.两性离子聚合物：超越聚乙二醇的蛋白质偶联新范式。
ChemMedChem. 2023 Oct 17;18(20):e202300245. doi: 10.1002/cmdc.202300245. Epub 2023 Sep 20.
10
Biocompatible long-circulating star carboxybetaine polymers.生物相容性长循环星形羧基甜菜碱聚合物
J Mater Chem B. 2015 Jan 21;3(3):440-448. doi: 10.1039/c4tb01477d. Epub 2014 Nov 18.

引用本文的文献

1
Synthesis of polymer-clindamycin conjugates through lipase-catalyzed esterification and RAFT polymerization.通过脂肪酶催化酯化和可逆加成-断裂链转移（RAFT）聚合合成聚合物-克林霉素缀合物。
Polymer (Guildf). 2025 Jan 15;317. doi: 10.1016/j.polymer.2024.127965. Epub 2024 Dec 18.
2
Layer-by-Layer Coated Alginate Hydrogels with Antibacterial Activity Based on Bacteriophage and Curcumin Combination.基于噬菌体与姜黄素组合的具有抗菌活性的逐层包覆藻酸盐水凝胶
ACS Omega. 2025 Jul 23;10(30):33108-33123. doi: 10.1021/acsomega.5c02562. eCollection 2025 Aug 5.
3
Co-Encapsulation of Multiple Antineoplastic Agents in Liposomes by Exploring Microfluidics.

本文引用的文献

1
PEGylated therapeutics in the clinic.临床中的聚乙二醇化治疗药物。
Bioeng Transl Med. 2023 Sep 22;9(1):e10600. doi: 10.1002/btm2.10600. eCollection 2024 Jan.
2
Integrating Liquification of the Gelated Tumor Interstitium around Nanomedicines with Biconditional GD2-Targeting for Precise and Safe Chemotherapy.将纳米药物周围凝胶状肿瘤间质的液化与双条件GD2靶向相结合以实现精确且安全的化疗
Adv Mater. 2023 Dec;35(49):e2304594. doi: 10.1002/adma.202304594. Epub 2023 Oct 26.
3
Ring-Opening Polymerization of Cyclic Acetals: Strategy for both Recyclable and Degradable Materials.
通过微流控技术实现多种抗肿瘤药物在脂质体中的共包封
Int J Mol Sci. 2025 Apr 17;26(8):3820. doi: 10.3390/ijms26083820.
4
Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment.合成聚合物辅助反义寡核苷酸递送：精准疾病治疗的靶向方法
Beilstein J Nanotechnol. 2025 Mar 27;16:435-463. doi: 10.3762/bjnano.16.34. eCollection 2025.
环状缩醛的开环聚合：可回收和可降解材料的策略。
Macromol Rapid Commun. 2023 Jul;44(13):e2300099. doi: 10.1002/marc.202300099. Epub 2023 Apr 14.
4
Robust Construction of Supersmall Zwitterionic Micelles Based on Hyperbranched Polycarbonates Mediates High Tumor Accumulation.基于超支化聚碳酸酯构建的超小两性离子胶束的稳健结构介导了高肿瘤蓄积。
ACS Appl Mater Interfaces. 2023 Jan 18;15(2):2725-2736. doi: 10.1021/acsami.2c20056. Epub 2023 Jan 4.
5
Impact of anti-PEG antibodies induced by SARS-CoV-2 mRNA vaccines.由 SARS-CoV-2 mRNA 疫苗引起的抗聚乙二醇抗体的影响。
Nat Rev Immunol. 2023 Mar;23(3):135-136. doi: 10.1038/s41577-022-00825-x.
6
Stimuli-responsive hydrogels for manipulation of cell microenvironment: From chemistry to biofabrication technology.用于细胞微环境调控的刺激响应性水凝胶：从化学到生物制造技术
Prog Polym Sci. 2019 Nov;98. doi: 10.1016/j.progpolymsci.2019.101147. Epub 2019 Jul 12.
7
Zwitterionic Biomaterials.两性离子生物材料
Chem Rev. 2022 Dec 14;122(23):17073-17154. doi: 10.1021/acs.chemrev.2c00344. Epub 2022 Oct 6.
8
Understanding the Role and Impact of Poly (Ethylene Glycol) (PEG) on Nanoparticle Formulation: Implications for COVID-19 Vaccines.了解聚乙二醇（PEG）在纳米颗粒制剂中的作用和影响：对COVID-19疫苗的启示。
Front Bioeng Biotechnol. 2022 Jun 7;10:882363. doi: 10.3389/fbioe.2022.882363. eCollection 2022.
9
Introduction: Polymeric Biomaterials.引言：聚合物生物材料
Chem Rev. 2021 Sep 22;121(18):10789-10791. doi: 10.1021/acs.chemrev.1c00354.
10
Polyethylene Glycol Immunogenicity: Theoretical, Clinical, and Practical Aspects of Anti-Polyethylene Glycol Antibodies.聚乙二醇免疫原性：抗聚乙二醇抗体的理论、临床和实际问题。
ACS Nano. 2021 Sep 28;15(9):14022-14048. doi: 10.1021/acsnano.1c05922. Epub 2021 Sep 1.