• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

疏水性鏻离子液体对粘康酸的反应萃取——实验、建模及人工神经网络优化

Reactive extraction of muconic acid by hydrophobic phosphonium ionic liquids - Experimental, modelling and optimisation with Artificial Neural Networks.

作者信息

Blaga Alexandra Cristina, Dragoi Elena Niculina, Tucaliuc Alexandra, Kloetzer Lenuta, Puitel Adrian-Catalin, Cascaval Dan, Galaction Anca Irina

机构信息

"Gheorghe Asachi" Technical University of Iasi, "Cristofor Simionescu" Faculty of Chemical Engineering and Environmental Protection, Iasi, Romania.

"Grigore T. Popa" University of Medicine and Pharmacy, Faculty of Medical Bioengineering, Iasi, Romania.

出版信息

Heliyon. 2024 Aug 10;10(16):e36113. doi: 10.1016/j.heliyon.2024.e36113. eCollection 2024 Aug 30.

DOI:10.1016/j.heliyon.2024.e36113
PMID:39247304
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11379585/
Abstract

Muconic acid is a six-carbon dicarboxylic acid with conjugated double bonds that finds extensive use in the food (additive), chemical (production of adipic acid, monomer for functional resins and bio-plastics), and pharmaceutical sectors. The biosynthesis of muconic acid has been the subject of recent industrial and scientific attention. However, because of its low concentration in aqueous solutions and high purity requirement, downstream separation presents a significant problem. Artificial Neural Networks and Differential Evolution were used to optimize process parameters for the recovery of muconic acid from aqueous streams in a system with n-heptane as an organic diluent and ionic liquids as extractants. The system using 120 g/L tri-hexyl-tetra-decyl-phosphonium decanoate dissolved in n-heptane, pH of the aqueous phase 3, 20 min contact time, and 45 °C temperature assured a muconic acid extraction efficiency of 99,24 %. Low stripping efficiency compared to extraction efficiency was observed for the optimum conditions on the extraction step (120 g/L ionic liquids dissolved in heptane). However, re-extraction efficiencies obtained for the recycled organic phase in three consecutive stages were close to the first extraction stage. The mechanism analysis proved that the analysed phosphonium ionic liquids (PILSs) extracts only undissociated molecules of muconic acid through H-bonding.

摘要

粘康酸是一种具有共轭双键的六碳二羧酸，在食品（添加剂）、化工（生产己二酸，功能性树脂和生物塑料的单体）和制药领域有广泛应用。粘康酸的生物合成是近期工业和科学关注的主题。然而，由于其在水溶液中的浓度较低且对纯度要求较高，下游分离存在重大问题。人工神经网络和差分进化算法被用于优化从含水物流中回收粘康酸的工艺参数，该系统以正庚烷为有机稀释剂，离子液体为萃取剂。使用溶解在正庚烷中的120 g/L三己基十四烷基磷酸癸酯、水相pH值为3、接触时间20分钟以及温度45°C的系统，确保了粘康酸的萃取效率为99.24%。在萃取步骤的最佳条件下（溶解在庚烷中的120 g/L离子液体），观察到与萃取效率相比，反萃效率较低。然而，在三个连续阶段中，循环有机相获得的再萃取效率接近第一萃取阶段。机理分析证明，所分析的磷鎓离子液体（PILSs）仅通过氢键萃取未离解的粘康酸分子。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbc4/11379585/117b8c7622c8/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbc4/11379585/f441f5099d5e/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbc4/11379585/d256515fc92b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbc4/11379585/6b777854083a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbc4/11379585/4155a0eef16c/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbc4/11379585/4075904c4fa0/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbc4/11379585/5b0c74f2d248/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbc4/11379585/143265fbaaa2/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbc4/11379585/b7ddee54fd54/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbc4/11379585/0193acb65552/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbc4/11379585/1ce8994a1662/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbc4/11379585/117b8c7622c8/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbc4/11379585/f441f5099d5e/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbc4/11379585/d256515fc92b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbc4/11379585/6b777854083a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbc4/11379585/4155a0eef16c/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbc4/11379585/4075904c4fa0/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbc4/11379585/5b0c74f2d248/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbc4/11379585/143265fbaaa2/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbc4/11379585/b7ddee54fd54/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbc4/11379585/0193acb65552/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbc4/11379585/1ce8994a1662/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbc4/11379585/117b8c7622c8/gr10.jpg

相似文献

1
Reactive extraction of muconic acid by hydrophobic phosphonium ionic liquids - Experimental, modelling and optimisation with Artificial Neural Networks.疏水性鏻离子液体对粘康酸的反应萃取——实验、建模及人工神经网络优化
Heliyon. 2024 Aug 10;10(16):e36113. doi: 10.1016/j.heliyon.2024.e36113. eCollection 2024 Aug 30.
2
Folic Acid Ionic-Liquids-Based Separation: Extraction and Modelling.叶酸离子液体分离：萃取与建模。
Molecules. 2023 Apr 10;28(8):3339. doi: 10.3390/molecules28083339.
3
Extraction of phenolic pollutants from industrial wastewater using a bulk ionic liquid membrane technique.采用本体离子液体膜技术从工业废水中提取酚类污染物。
Environ Technol. 2022 Mar;43(7):1038-1049. doi: 10.1080/09593330.2020.1813209. Epub 2020 Sep 2.
4
Phosphonium ionic liquids as extractants for recovery of ruthenium(III) from acidic aqueous solutions.鏻离子液体作为从酸性水溶液中回收钌(III)的萃取剂。
Chem Zvesti. 2017;71(6):1065-1072. doi: 10.1007/s11696-016-0027-1. Epub 2016 Dec 21.
5
Influence of the ionic liquid cation on the solvent extraction of trivalent rare-earth ions by mixtures of Cyanex 923 and ionic liquids.离子液体阳离子对Cyanex 923与离子液体混合物萃取三价稀土离子的影响。
Dalton Trans. 2015 Jan 21;44(3):1379-87. doi: 10.1039/c4dt02766c.
6
Enhanced extraction of bovine serum albumin with aqueous biphasic systems of phosphonium- and ammonium-based ionic liquids.基于鏻盐和铵盐离子液体的双水相体系强化提取牛血清白蛋白
J Biotechnol. 2015 Jul 20;206:17-25. doi: 10.1016/j.jbiotec.2015.03.028. Epub 2015 Apr 9.
7
Separation of neodymium and dysprosium by solvent extraction using ionic liquids combined with neutral extractants: batch and mixer-settler experiments.使用离子液体与中性萃取剂结合通过溶剂萃取分离钕和镝：间歇式和混合澄清槽实验
RSC Adv. 2020 Jan 2;10(1):307-316. doi: 10.1039/c9ra08996a. eCollection 2019 Dec 20.
8
Synthesis of fatty acid-based ammonium ionic liquids and their application for extraction of Co(II) and Ni(II) metals ions from aqueous solution.脂肪酸基季铵离子液体的合成及其在水溶液中萃取 Co(II)和 Ni(II)金属离子的应用。
Chemosphere. 2022 Nov;307(Pt 2):135787. doi: 10.1016/j.chemosphere.2022.135787. Epub 2022 Jul 21.
9
In-situ muconic acid extraction reveals sugar consumption bottleneck in a xylose-utilizing Saccharomyces cerevisiae strain.原位黏康酸提取揭示了一株利用木糖的酿酒酵母菌株中糖消耗的瓶颈。
Microb Cell Fact. 2021 Jun 7;20(1):114. doi: 10.1186/s12934-021-01594-3.
10
Influence of Anion and Cation Structure of Ionic Liquids on Carboxylic Acids Extraction.离子液体的阴离子和阳离子结构对羧酸萃取的影响
Front Chem. 2019 Mar 14;7:117. doi: 10.3389/fchem.2019.00117. eCollection 2019.

本文引用的文献

1
Corynebacterium glutamicum cell factory design for the efficient production of cis, cis-muconic acid.解脂亚洛氏菌细胞工厂设计用于高效生产顺, 顺-粘康酸。
Metab Eng. 2024 Mar;82:225-237. doi: 10.1016/j.ymben.2024.02.005. Epub 2024 Feb 17.
2
Screening non-conventional yeasts for acid tolerance and engineering Pichia occidentalis for production of muconic acid.筛选耐酸非传统酵母并对产粘康酸毕赤酵母进行工程改造。
Nat Commun. 2023 Aug 31;14(1):5294. doi: 10.1038/s41467-023-41064-5.
3
Modeling and Optimization of Ultrasound-Assisted Extraction of Bioactive Compounds from Leaves Using Response Surface Methodology and Artificial Neural Network Coupled with Genetic Algorithm.
使用响应面法、人工神经网络结合遗传算法对超声辅助从叶片中提取生物活性化合物进行建模与优化
Foods. 2023 May 8;12(9):1925. doi: 10.3390/foods12091925.
4
Muconic acid production from glucose and xylose in Pseudomonas putida via evolution and metabolic engineering.通过进化和代谢工程，在恶臭假单胞菌中从葡萄糖和木糖生产粘康酸。
Nat Commun. 2022 Aug 22;13(1):4925. doi: 10.1038/s41467-022-32296-y.
5
Optimization of accelerated solvent extraction of ellagitannins in black raspberry seeds using artificial neural network coupled with genetic algorithm.采用人工神经网络结合遗传算法优化黑莓种子中鞣花单宁的加速溶剂萃取。
Food Chem. 2022 Dec 1;396:133712. doi: 10.1016/j.foodchem.2022.133712. Epub 2022 Jul 14.
6
Removal of Perfluorooctanoic Acid from Water Using a Hydrophobic Ionic Liquid Selected Using the Conductor-like Screening Model for Realistic Solvents.使用导电机理相似性实溶剂模型选择的疏水离子液体从水中去除全氟辛酸
Environ Sci Technol. 2022 May 17;56(10):6445-6454. doi: 10.1021/acs.est.1c08537. Epub 2022 Apr 29.
7
An integrated yeast-based process for cis,cis-muconic acid production.基于酵母的顺式,顺式-粘康酸生产的集成工艺。
Biotechnol Bioeng. 2022 Feb;119(2):376-387. doi: 10.1002/bit.27992. Epub 2021 Nov 24.
8
In-syringe ionic liquid-dispersive liquid-liquid microextraction coupled with HPLC for the determination of trans,trans-muconic acid in human urine sample.在注射器内离子液体分散液液微萃取与 HPLC 联用测定人尿液样品中反,反-粘康酸。
J Sep Sci. 2021 Aug;44(16):3126-3136. doi: 10.1002/jssc.202100044. Epub 2021 Jun 25.
9
Extraction of PFOA from dilute wastewater using ionic liquids that are dissolved in N-octanol.使用溶解在正辛醇中的离子液体从稀废水中提取全氟辛酸。
J Hazard Mater. 2021 Feb 15;404(Pt B):124091. doi: 10.1016/j.jhazmat.2020.124091. Epub 2020 Sep 25.
10
Reactive Extraction of Malic Acid using Trioctylamine in 1-Decanol: Equilibrium Studies by Response Surface Methodology Using Box Behnken Optimization Technique.用三辛胺从 1-癸醇中反萃苹果酸：响应面法用 Box-Behnken 优化技术进行平衡研究。
Sci Rep. 2020 Feb 12;10(1):2400. doi: 10.1038/s41598-020-59273-z.