Pan Ying, Zhao Mengjie, Song Tiantian, Tang Jia, Kuang Ming, Liu Hongying, Zhong Shao
Department of General Practice, Kunshan Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu, People's Republic of China.
Hangzhou Kang Ming Information Technology Co., Ltd, Hangzhou, Zhejiang, People's Republic of China.
Diabetes Metab Syndr Obes. 2024 Sep 4;17:3325-3333. doi: 10.2147/DMSO.S478287. eCollection 2024.
Insulin resistance (IR) is the major mechanism in the pathogenesis of type 2 diabetes mellitus (T2DM). Early identification of IR is of great significance for preventing the onset of T2DM and delaying the progression of the disease. Previous studies have shown that triglyceride-glucose (TyG) index can be used as an effective surrogate marker for IR. There is a significant correlation between TyG index and T2DM and its common complications. In addition, the predictive efficacy of TyG index is better than that of other IR surrogate indicators. TyG index may not only become an important marker to identify people at high risk of T2DM and its complications, but is also expected to become a strong predictor of the prognosis of these diseases. However, there are still some challenges in the widespread application of TyG index in clinical practice. In the future, more high-quality studies are needed to clarify the assessment methods of TyG index for the prognosis of T2DM and its complications. Further investigations of the relationship between TyG index and T2DM and its complications will be expected to provide new ideas and methods for the prevention and treatment of T2DM and its complications.
胰岛素抵抗（IR）是2型糖尿病（T2DM）发病机制中的主要机制。早期识别IR对于预防T2DM的发生和延缓疾病进展具有重要意义。既往研究表明，甘油三酯-葡萄糖（TyG）指数可作为IR的有效替代指标。TyG指数与T2DM及其常见并发症之间存在显著相关性。此外，TyG指数的预测效能优于其他IR替代指标。TyG指数不仅可能成为识别T2DM及其并发症高危人群的重要标志物，还有望成为这些疾病预后的有力预测指标。然而，TyG指数在临床实践中的广泛应用仍存在一些挑战。未来，需要更多高质量研究来明确TyG指数对T2DM及其并发症预后的评估方法。对TyG指数与T2DM及其并发症之间关系的进一步研究，有望为T2DM及其并发症的防治提供新的思路和方法。
