Wu Juan, Li Gui-Jun, Niu Jie, Wen Fei, Han Li
Department of Ophthalmology, The First People's Hospital of Xining, Xining 810000, Qinghai Province, China.
World J Clin Cases. 2024 Sep 6;12(25):5665-5672. doi: 10.12998/wjcc.v12.i25.5665.
Dry eye is a common eye disease. Artificial tears supplements are widely used for the treatment of dry eyes. However, multiple adverse effects have been observed in patients receiving long-term treatment with artificial tears, which may affect the therapeutic effect.
To analyze the characteristics of interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) levels in patients with dry eye and the therapeutic effect of artificial tears combined with cyclosporine A.
A total of 124 dry eye patients treated at The First People's Hospital of Xining from April 2020 to April 2022 were selected as the observation group, while 20 healthy individuals served as the control group during the same period. Levels of inflammatory markers, including IL-1β, IL-6, and TNF-α, were analyzed. The observation group was further divided into a study group and a control group, each consisting of 62 patients. The control group received artificial tears, whereas the study group received a combination of artificial tears and cyclosporine A. Inflammatory markers, Schirmer's test (SIT), tear break-up time (TBUT), corneal fluorescein staining (CFS), National Eye Institute Visual Function Questionnaire-25 (NEI-VFQ-25) scores, and adverse events (AEs) were compared between the two groups.
The observation group exhibited significantly elevated serum levels of IL-1β, IL-6, and TNF-α in comparison to the healthy group. Following treatment, the study group demonstrated substantial reductions in IL-1β, IL-6, and TNF-α levels relative to the control group. Moreover, after treatment, the study group experienced a marked decrease in CFS scores and significant increases in both SIT and BUT levels when compared to the control group. Additionally, significant improvements were observed in the primary symptom of dry eye and secondary symptoms such as photophobia, foreign body sensation, fatigue, red eye, and burning sensation within the study group. Furthermore, post-treatment NEI-VFQ-25 scores across all dimensions exhibited significant enhancements in the study group compared to the control group ( < 0.05). It is noteworthy that significant AEs were reported in both groups throughout the treatment period.
Cyclosporine A combined with artificial tears is effective in treating dry eye, yielding enhanced outcomes by improving SIT and TBUT levels, reducing CFS scores, and ameliorating vision-related quality of life.
干眼症是一种常见的眼科疾病。人工泪液补充剂被广泛用于治疗干眼症。然而，长期接受人工泪液治疗的患者出现了多种不良反应，这可能会影响治疗效果。
分析干眼症患者白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）水平的特征以及人工泪液联合环孢素A的治疗效果。
选取2020年4月至2022年4月在西宁市第一人民医院接受治疗的124例干眼症患者作为观察组，同期选取20例健康个体作为对照组。分析包括IL-1β、IL-6和TNF-α在内的炎症标志物水平。观察组进一步分为研究组和对照组，每组62例患者。对照组接受人工泪液治疗，而研究组接受人工泪液联合环孢素A治疗。比较两组的炎症标志物、泪液分泌试验（SIT）、泪膜破裂时间（TBUT）、角膜荧光素染色（CFS）、美国国立眼科研究所视觉功能问卷-25（NEI-VFQ-25）评分及不良事件（AE）。
与健康组相比，观察组血清IL-1β、IL-6和TNF-α水平显著升高。治疗后，研究组的IL-1β、IL-6和TNF-α水平相对于对照组大幅降低。此外，治疗后，与对照组相比，研究组的CFS评分显著降低，SIT和BUT水平显著升高。此外，研究组干眼症的主要症状以及畏光、异物感、疲劳、眼红和烧灼感等次要症状均有明显改善。此外，与对照组相比，研究组治疗后NEI-VFQ-25各维度评分均有显著提高（<0.05）。值得注意的是，治疗期间两组均报告了明显的不良事件。
环孢素A联合人工泪液治疗干眼症有效，通过提高SIT和TBUT水平、降低CFS评分以及改善视力相关生活质量产生更好的效果。
