肠道、尿液及阴道微生物群落在女性尿路感染发病机制中的作用及微生物群疗法的思考
The Role of the Gut, Urine, and Vaginal Microbiomes in the Pathogenesis of Urinary Tract Infection in Women and Consideration of Microbiome Therapeutics.
作者信息
Naji Amal, Siskin Drew, Woodworth Michael H, Lee John R, Kraft Colleen S, Mehta Nirja
机构信息
Piedmont Hospital, Atlanta, Georgia, USA.
Emory University, Atlanta, Georgia, USA.
出版信息
Open Forum Infect Dis. 2024 Aug 19;11(9):ofae471. doi: 10.1093/ofid/ofae471. eCollection 2024 Sep.
Abstract
The gut, urine, and vaginal microbiomes play significant roles in the pathogenesis of recurrent urinary tract infections (rUTIs). Analysis of these microbiota has shown distinct associations with urinary tract infections. Encouraging data indicate that rUTIs may be responsive to microbiome treatments such as fecal microbiota transplantation, expanding potential treatments beyond antibiotics, hydration, and behavioral interventions. If successful, these nonantibiotic therapies have the potential to increase time between rUTI episodes and reduce the prevalence of multidrug-resistant organisms. In this review, we discuss the role of the 3 microbiomes in the pathogenesis of rUTI and utilization of live biotherapeutic products as therapy for rUTI.
摘要
肠道、尿液和阴道微生物群落在复发性尿路感染（rUTIs）的发病机制中发挥着重要作用。对这些微生物群的分析表明，它们与尿路感染存在明显的关联。令人鼓舞的数据表明，rUTIs可能对微生物群治疗有反应，如粪便微生物群移植，从而将潜在治疗方法扩展到抗生素、水化和行为干预之外。如果成功，这些非抗生素疗法有可能延长rUTI发作的间隔时间，并降低多重耐药菌的流行率。在这篇综述中，我们讨论了这三种微生物群在rUTI发病机制中的作用以及使用活体生物治疗产品治疗rUTI的情况。
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