• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
The Role of the Gut, Urine, and Vaginal Microbiomes in the Pathogenesis of Urinary Tract Infection in Women and Consideration of Microbiome Therapeutics.肠道、尿液及阴道微生物群落在女性尿路感染发病机制中的作用及微生物群疗法的思考
Open Forum Infect Dis. 2024 Aug 19;11(9):ofae471. doi: 10.1093/ofid/ofae471. eCollection 2024 Sep.
2
Gut microbiome correlates of recurrent urinary tract infection: a longitudinal, multi-center study.复发性尿路感染的肠道微生物群相关性：一项纵向多中心研究
EClinicalMedicine. 2024 Apr 26;71:102490. doi: 10.1016/j.eclinm.2024.102490. eCollection 2024 May.
3
The effect of local estrogen therapy on the urinary microbiome composition of postmenopausal women with and without recurrent urinary tract infections.局部雌激素治疗对有和无复发性尿路感染的绝经后妇女尿微生物组组成的影响。
Int Urogynecol J. 2022 Aug;33(8):2107-2117. doi: 10.1007/s00192-021-04832-9. Epub 2021 May 18.
4
[Urinary bladder microbiome analysis and probiotic treatment options for women with recurrent urinary tract infections].[复发性尿路感染女性的膀胱微生物群分析及益生菌治疗方案]
Urologe A. 2022 Jan;61(1):41-51. doi: 10.1007/s00120-021-01621-6. Epub 2021 Aug 23.
5
Recurrent urinary tract infection and estrogen shape the taxonomic ecology and function of the postmenopausal urogenital microbiome.复发性尿路感染和雌激素塑造绝经后泌尿生殖系统微生物组的分类生态和功能。
Cell Rep Med. 2022 Oct 18;3(10):100753. doi: 10.1016/j.xcrm.2022.100753. Epub 2022 Sep 30.
6
Microbiota Ecosystem in Recurrent Cystitis and the Immunological Microenvironment of Urothelium.复发性膀胱炎中的微生物群生态系统与尿路上皮的免疫微环境
Healthcare (Basel). 2023 Feb 10;11(4):525. doi: 10.3390/healthcare11040525.
7
Longitudinal multi-omics analyses link gut microbiome dysbiosis with recurrent urinary tract infections in women.纵向多组学分析将肠道微生物失调与女性复发性尿路感染联系起来。
Nat Microbiol. 2022 May;7(5):630-639. doi: 10.1038/s41564-022-01107-x. Epub 2022 May 2.
8
Defining the relationship between vaginal and urinary microbiomes.定义阴道和尿路微生物组之间的关系。
Am J Obstet Gynecol. 2020 Feb;222(2):154.e1-154.e10. doi: 10.1016/j.ajog.2019.08.011. Epub 2019 Aug 14.
9
Recurrent urinary tract infections and prophylactic antibiotic use in women: a cross-sectional study in primary care.妇女复发性尿路感染和预防性抗生素使用：初级保健中的横断面研究。
Br J Gen Pract. 2024 Aug 29;74(746):e619-e627. doi: 10.3399/BJGP.2024.0015. Print 2024 Sep.
10
Evidence-based review of nonantibiotic urinary tract infection prevention strategies for women: a patient-centered approach.基于证据的女性非抗生素预防尿路感染策略综述：以患者为中心的方法
Curr Opin Urol. 2023 May 1;33(3):187-192. doi: 10.1097/MOU.0000000000001082. Epub 2023 Mar 2.

引用本文的文献

1
Fecal microbiota transplant as treatment for recurrent urinary tract infections: a proof-of-concept study.粪便微生物群移植治疗复发性尿路感染：一项概念验证研究。
Eur J Clin Microbiol Infect Dis. 2025 Jul 2. doi: 10.1007/s10096-025-05202-9.
2
Effects of Selective Serotonin Reuptake Inhibitors and Ondansetron on Urinary Tract Infections in Pregnancy.选择性5-羟色胺再摄取抑制剂和昂丹司琼对妊娠期尿路感染的影响。
Reprod Sci. 2025 Apr;32(4):1155-1165. doi: 10.1007/s43032-025-01826-6. Epub 2025 Mar 5.

本文引用的文献

1
Epidemiology and microbiology of recurrent UTI in women in the community in Oxfordshire, UK.英国牛津郡社区女性复发性尿路感染的流行病学与微生物学研究
JAC Antimicrob Resist. 2024 Jan 10;6(1):dlad156. doi: 10.1093/jacamr/dlad156. eCollection 2024 Feb.
2
Fecal microbiota transplantation promotes reduction of antimicrobial resistance by strain replacement.粪便微生物群移植通过菌株替换促进抗菌药物耐药性的减少。
Sci Transl Med. 2023 Nov;15(720):eabo2750. doi: 10.1126/scitranslmed.abo2750. Epub 2023 Nov 1.
3
Reduction in urinary tract infections in patients treated with fecal microbiota transplantation for recurrent Clostridioides difficile infection.粪便微生物群移植治疗复发性艰难梭菌感染患者中尿路感染的减少。
Eur J Clin Microbiol Infect Dis. 2023 Aug;42(8):1037-1041. doi: 10.1007/s10096-023-04635-4. Epub 2023 Jun 23.
4
Microbiota Ecosystem in Recurrent Cystitis and the Immunological Microenvironment of Urothelium.复发性膀胱炎中的微生物群生态系统与尿路上皮的免疫微环境
Healthcare (Basel). 2023 Feb 10;11(4):525. doi: 10.3390/healthcare11040525.
5
Gut microbiome in the emergence of antibiotic-resistant bacterial pathogens.肠道微生物群在抗生素耐药性细菌病原体出现中的作用。
Prog Mol Biol Transl Sci. 2022;192(1):1-31. doi: 10.1016/bs.pmbts.2022.07.009. Epub 2022 Sep 3.
6
Transmission of Antibiotic-Susceptible Causing Urinary Tract Infections in a Fecal Microbiota Transplantation Recipient: Consequences for Donor Screening?粪便微生物群移植受者中引起尿路感染的抗生素敏感菌的传播：对供体筛查有何影响？
Open Forum Infect Dis. 2022 Jun 29;9(7):ofac324. doi: 10.1093/ofid/ofac324. eCollection 2022 Jul.
7
Commensal Urinary Lactobacilli Inhibit Major Uropathogens With Heterogeneity at Species and Strain Level.共生尿乳酸杆菌在种和菌株水平上具有异质性，可抑制主要尿路病原体。
Front Cell Infect Microbiol. 2022 Jun 23;12:870603. doi: 10.3389/fcimb.2022.870603. eCollection 2022.
8
The urinary microbiome and biological therapeutics: Novel therapies for urinary tract infections.尿微生物组与生物治疗学：尿路感染的新型疗法。
Microbiol Res. 2022 Jun;259:127010. doi: 10.1016/j.micres.2022.127010. Epub 2022 Mar 20.
9
Urine and vaginal microbiota compositions of postmenopausal and premenopausal women differ regardless of recurrent urinary tract infection and renal transplant status.绝经后和绝经前女性的尿液和阴道微生物群落组成存在差异，无论是否反复发生尿路感染和肾移植情况如何。
Sci Rep. 2022 Feb 17;12(1):2698. doi: 10.1038/s41598-022-06646-1.
10
Faecal microbiota transplantation reduces amounts of antibiotic resistance genes in patients with multidrug-resistant organisms.粪便微生物群移植可减少多重耐药菌患者的抗生素耐药基因数量。
Antimicrob Resist Infect Control. 2022 Jan 29;11(1):20. doi: 10.1186/s13756-022-01064-4.

肠道、尿液及阴道微生物群落在女性尿路感染发病机制中的作用及微生物群疗法的思考

The Role of the Gut, Urine, and Vaginal Microbiomes in the Pathogenesis of Urinary Tract Infection in Women and Consideration of Microbiome Therapeutics.

作者信息

Naji Amal, Siskin Drew, Woodworth Michael H, Lee John R, Kraft Colleen S, Mehta Nirja

机构信息

Piedmont Hospital, Atlanta, Georgia, USA.

Emory University, Atlanta, Georgia, USA.

出版信息

Open Forum Infect Dis. 2024 Aug 19;11(9):ofae471. doi: 10.1093/ofid/ofae471. eCollection 2024 Sep.

DOI:10.1093/ofid/ofae471
PMID:39247802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11378400/
Abstract

The gut, urine, and vaginal microbiomes play significant roles in the pathogenesis of recurrent urinary tract infections (rUTIs). Analysis of these microbiota has shown distinct associations with urinary tract infections. Encouraging data indicate that rUTIs may be responsive to microbiome treatments such as fecal microbiota transplantation, expanding potential treatments beyond antibiotics, hydration, and behavioral interventions. If successful, these nonantibiotic therapies have the potential to increase time between rUTI episodes and reduce the prevalence of multidrug-resistant organisms. In this review, we discuss the role of the 3 microbiomes in the pathogenesis of rUTI and utilization of live biotherapeutic products as therapy for rUTI.

摘要

肠道、尿液和阴道微生物群落在复发性尿路感染（rUTIs）的发病机制中发挥着重要作用。对这些微生物群的分析表明，它们与尿路感染存在明显的关联。令人鼓舞的数据表明，rUTIs可能对微生物群治疗有反应，如粪便微生物群移植，从而将潜在治疗方法扩展到抗生素、水化和行为干预之外。如果成功，这些非抗生素疗法有可能延长rUTI发作的间隔时间，并降低多重耐药菌的流行率。在这篇综述中，我们讨论了这三种微生物群在rUTI发病机制中的作用以及使用活体生物治疗产品治疗rUTI的情况。