Clinical Medical College of Chengdu Medical College, Chengdu, Sichuan, China.
Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China.
Front Endocrinol (Lausanne). 2024 Aug 23;15:1418933. doi: 10.3389/fendo.2024.1418933. eCollection 2024.
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is correlated with metabolic deterioration in patients experiencing polycystic ovary syndrome (PCOS). Women diagnosed with PCOS exhibit a heightened prevalence of OSAHS. This meta-analysis aims to assess the morbidity of OSAHS in women affected by PCOS and to examine the differences in metabolism-related indicators between OSAHS-positive and OSAHS-negative in women with PCOS.
A comprehensive literature analysis of OSAHS morbidity in women with PCOS was conducted, utilizing databases such as CNKI, EMBASE, PubMed, Web of Science, and Wanfang. A comparison was carried out between patients with OSAHS-positive and those with OSAHS-negative in terms of their clinical characteristics and metabolic differences. The search language included English and Chinese. The acquired data were analyzed by employing RevMan 5.2 and Stata 11.0. Continuous variables with the same units were combined and analyzed through weighted mean differences (WMDs) as effect sizes, while continuous variables with different units were combined and analyzed through standardized mean differences (SMDs) as effect sizes. A conjoint analysis was performed on the basis of I value, using either a fixed effect model (I ≤ 50%) or a random effect model (I > 50%).
A total of 21 articles met the inclusion criteria for this study. The findings indicated that 20.8% of women with PCOS were found to have comorbid OSAHS. The subjects were categorized into various subgroups for meta-analysis on the basis of race, age, disease severity, body mass index (BMI), and diagnostic criteria of PCOS. The results revealed high morbidity of OSAHS in all subgroups. In addition, most metabolic indicators and parameters of metabolic syndrome were notably worse in women suffering from both PCOS and OSAHS in comparison to their counterparts solely diagnosed with PCOS.
The current literature indicates higher morbidity of OSAHS among women with PCOS, linking OSAHS with worse metabolic status and obesity in this population. Consequently, clinicians are advised to prioritize the detection and management of OSAHS in women with PCOS.
https://www.crd.york.ac.uk/PROSPERO/#myprospero PROSPERO, identifier (CRD42024528264).
阻塞性睡眠呼吸暂停低通气综合征（OSAHS）与多囊卵巢综合征（PCOS）患者的代谢恶化有关。患有 PCOS 的女性 OSAHS 的患病率更高。本荟萃分析旨在评估患有 PCOS 的女性 OSAHS 的发病率，并检查 PCOS 女性中 OSAHS 阳性与 OSAHS 阴性患者之间与代谢相关的指标差异。
对中国知网（CNKI）、Embase、PubMed、Web of Science 和万方等数据库中 PCOS 女性 OSAHS 发病率进行全面文献分析。比较 OSAHS 阳性和 OSAHS 阴性患者的临床特征和代谢差异。检索语言包括英语和中文。采用 RevMan 5.2 和 Stata 11.0 对获得的数据进行分析。对具有相同单位的连续变量进行合并分析，采用加权均数差（WMD）作为效应量；对具有不同单位的连续变量进行合并分析，采用标准化均数差（SMD）作为效应量。根据 I ² 值，采用固定效应模型（I ≤ 50%）或随机效应模型（I > 50%）进行联合分析。
共有 21 篇文章符合纳入标准。结果表明，20.8%的 PCOS 女性患有合并 OSAHS。根据种族、年龄、疾病严重程度、体重指数（BMI）和 PCOS 诊断标准，对受试者进行了亚组荟萃分析。结果表明，所有亚组的 OSAHS 发病率均较高。此外，与仅诊断为 PCOS 的患者相比，患有 PCOS 和 OSAHS 的女性的大多数代谢指标和代谢综合征参数均明显更差。
目前的文献表明，PCOS 女性 OSAHS 的发病率更高，将 OSAHS 与该人群的代谢状态恶化和肥胖联系起来。因此，临床医生应优先考虑在患有 PCOS 的女性中检测和管理 OSAHS。
https://www.crd.york.ac.uk/PROSPERO/#myprospero PROSPERO，标识符（CRD42024528264）。
