He Jie, Wang Chunmao, Li Wancheng
Clinical Medical College of Chengdu Medical College, Chengdu, People's Republic of China.
Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Chengdu Medical College, Chengdu, People's Republic of China.
Nat Sci Sleep. 2022 Dec 15;14:2189-2201. doi: 10.2147/NSS.S390272. eCollection 2022.
Laryngopharyngeal reflux (LPR) is a common disorder in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). This meta-analysis was carried out to evaluate the LPR prevalence in individuals with OSAHS and to analyze the correlation of LPR positivity with the clinical features of patients with OSAHS. A detailed review of the English and Chinese literature on the occurrence of LPR in patients with OSAHS was performed by employing online search tools such as PubMed, EMBASE, Web of Science, VIP, CNKI, WanFang, etc. Two researchers analyzed the studies for quality according to the STROBE standard checklist. The acquired data were analyzed using Stata 11.0 and R 3.6.1 software. The effect size was estimated and calculated using weighted mean difference (WMD) and correlation coefficients. Moreover, a combined analysis was performed by employing either a random- or fixed-effects model. Ultimately, 27 studies met our inclusion criteria. Our study revealed that the LPR prevalence in OSAHS patients was 49%. We carried out subgroup analyses as per OSAHS severity, ethnicity, and body mass index (BMI). The results suggested that the probability of LPR in European and American patients with OSAHS was higher, and the prevalence of LPR was higher in obese individuals and patients with severe OSAHS. Moreover, apnea-hypopnea index (AHI) and BMI were higher in LPR-positive OSAHS patients than in LPR-negative OSAHS patients, but no significant variation in age was observed in the two groups. Moreover, the reflux symptom index (RSI) scores and the reflux finding score (RFS) exhibited a positive correlation with AHI. The current literature shows a higher incidence of LPR in individuals with OSAHS (49%). The severity of AHI in individuals with OSAHS is associated with the presence of LPR. Patients with OSAHS accompanied by LPR showed higher BMI and AHI as compared to those patients with LPR-negative OSAHS.
喉咽反流（LPR）是阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者中的一种常见病症。本荟萃分析旨在评估OSAHS患者中LPR的患病率，并分析LPR阳性与OSAHS患者临床特征之间的相关性。通过使用PubMed、EMBASE、Web of Science、维普、知网、万方等在线搜索工具，对关于OSAHS患者中LPR发生情况的中英文文献进行了详细检索。两名研究人员根据STROBE标准清单对研究质量进行了分析。使用Stata 11.0和R 3.6.1软件对获取的数据进行分析。采用加权平均差（WMD）和相关系数估计并计算效应量。此外，采用随机效应模型或固定效应模型进行合并分析。最终，27项研究符合我们的纳入标准。我们的研究表明，OSAHS患者中LPR的患病率为49%。我们根据OSAHS严重程度、种族和体重指数（BMI）进行了亚组分析。结果表明，欧美OSAHS患者发生LPR的可能性更高，肥胖个体和重度OSAHS患者中LPR的患病率更高。此外，LPR阳性的OSAHS患者的呼吸暂停低通气指数（AHI）和BMI高于LPR阴性的OSAHS患者，但两组年龄无显著差异。此外，反流症状指数（RSI）评分和反流发现评分（RFS）与AHI呈正相关。当前文献显示，OSAHS患者中LPR的发生率较高（49%）。OSAHS患者的AHI严重程度与LPR的存在有关。与LPR阴性的OSAHS患者相比，伴有LPR的OSAHS患者的BMI和AHI更高。
