Rughetti Aurelia, Bharti Shreya, Savai Rajkumar, Barmpoutsi Spyridoula, Weigert Andreas, Atre Rajat, Siddiqi Faaiza, Sharma Rahul, Khabiya Rakhi, Hirani Nik, Baig Mirza S
Laboratory of Tumor Immunology & Cell Therapy, Department of Experimental Medicine, Policlinico Umberto I, University of Rome "Sapienza", Rome, Italy.
Department of Biosciences & Biomedical Engineering (BSBE), Indian Institute of Technology Indore (IITI), Indore, India.
Future Sci OA. 2024 Dec 31;10(1):2387961. doi: 10.1080/20565623.2024.2387961. Epub 2024 Sep 9.
Macrophages are integral part of the body's defense against pathogens and serve as vital regulators of inflammation. Adaptor molecules, featuring diverse domains, intricately orchestrate the recruitment and transmission of inflammatory responses through signaling cascades. Key domains involved in macrophage polarization include Toll-like receptors (TLRs), Src Homology2 (SH2) and other small domains, alongside receptor tyrosine kinases, crucial for pathway activation. This review aims to elucidate the enigmatic role of macrophage adaptor molecules in modulating macrophage activation, emphasizing their diverse roles and potential therapeutic and investigative avenues for further exploration.
巨噬细胞是机体抵御病原体的重要组成部分，也是炎症的关键调节因子。衔接分子具有多种结构域，通过信号级联反应巧妙地协调炎症反应的募集和传递。参与巨噬细胞极化的关键结构域包括Toll样受体（TLR）、Src同源2（SH2）结构域和其他小结构域，以及对信号通路激活至关重要的受体酪氨酸激酶。本综述旨在阐明巨噬细胞衔接分子在调节巨噬细胞激活中的神秘作用，强调其多样的作用以及进一步探索的潜在治疗和研究途径。
