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Enhancement of antitumor effect of cytotoxic agents by bestatin.

作者信息

Abe F, Shibuya K, Ashizawa J, Takahashi K, Horinishi H, Matsuda A, Ishizuka M, Takeuchi T, Umezawa H

出版信息

J Antibiot (Tokyo). 1985 Mar;38(3):411-4. doi: 10.7164/antibiotics.38.411.

Abstract

Bestatin enhanced the antitumor effects of mitomycin C, 5-fluorouracil and cis-dichlorodiammineplatinum against a syngeneic solid tumor of colon adenocarcinoma 26 in BALB/c mice. The enhancement was dependent on administration schedule. Bestatin administration after treatment with the cytotoxic agents was more effective than that made before the treatment.

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