贝司他汀增强细胞毒性药物的抗肿瘤作用。
Enhancement of antitumor effect of cytotoxic agents by bestatin.
作者信息
Abe F, Shibuya K, Ashizawa J, Takahashi K, Horinishi H, Matsuda A, Ishizuka M, Takeuchi T, Umezawa H
出版信息
J Antibiot (Tokyo). 1985 Mar;38(3):411-4. doi: 10.7164/antibiotics.38.411.
PMID:3924871
Abstract
Bestatin enhanced the antitumor effects of mitomycin C, 5-fluorouracil and cis-dichlorodiammineplatinum against a syngeneic solid tumor of colon adenocarcinoma 26 in BALB/c mice. The enhancement was dependent on administration schedule. Bestatin administration after treatment with the cytotoxic agents was more effective than that made before the treatment.
摘要
贝司他汀增强了丝裂霉素C、5-氟尿嘧啶和顺二氯二氨铂对BALB/c小鼠同基因结肠腺癌26实体瘤的抗肿瘤作用。这种增强作用取决于给药方案。在使用细胞毒性药物治疗后给予贝司他汀比在治疗前给予更有效。
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