State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Institute of Fiber Materials and Devices, and Laboratory of Advanced Materials, Fudan University, Shanghai, 200438, China.
J Mater Chem B. 2024 Sep 25;12(37):9206-9212. doi: 10.1039/d4tb01426j.
Fiber organic electrochemical transistors (OECTs) hold significant promise for bio-signal amplification due to their minimally invasive and seamless integration with biological tissues. However, their use in monitoring rapid physiological changes, such as electrophysiological signals, has been constrained by slow response time, arising from their extensive channel dimensions. Here, we introduce a novel fiber OECT designed with a micro-scale vertical channel (F-vOECT) that substantially reduces the response time by an order of magnitude to 12 ms and achieves a maximum transconductance of 16 mS at zero gate bias, marking a substantial improvement over previous fiber OECTs. This compact and flexible fiber device demonstrates robust performance under cyclic switching, dynamic deformation and exhibits excellent biocompatibility. When subcutaneously implanted in rats, the F-vOECT enables stable, continuous electrocardiogram monitoring for 7 days, successfully identifying episodes of atrioventricular block. These capabilities illustrate its potential for clinical electrophysiological diagnostics. The design strategy of F-vOECT opens new avenues for developing fast-responsive fiber bioelectronic devices.
纤维有机电化学晶体管（OECT）因其对生物组织的微创和无缝集成，在生物信号放大方面具有重要的应用前景。然而，由于其通道尺寸较大，其在监测快速生理变化（如电生理信号）方面的应用受到了响应时间慢的限制。在这里，我们引入了一种新型的纤维 OECT，其采用了微尺度垂直通道（F-vOECT）设计，将响应时间大幅缩短至 12ms，在零栅偏压下实现了 16mS 的最大跨导，相比于之前的纤维 OECT 有了显著的提升。这种紧凑且灵活的纤维器件在循环开关、动态变形下表现出了稳健的性能，并且具有优异的生物相容性。当将其植入大鼠的皮下时，F-vOECT 能够稳定、连续地监测 7 天的心电图，成功识别出房室传导阻滞的发作。这些性能表明它有用于临床电生理诊断的潜力。F-vOECT 的设计策略为开发快速响应的纤维生物电子器件开辟了新的途径。
