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Clopidogrel: Drug of the Past or Drug of the Future?

作者信息

De Servi Stefano, Landi Antonio

机构信息

Department of Molecular Medicine, University of Pavia, 27100, Pavia, Italy.

Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale (EOC), CH-6900, Lugano, Switzerland.

出版信息

Cardiovasc Drugs Ther. 2024 Dec;38(6):1073-1076. doi: 10.1007/s10557-024-07629-2. Epub 2024 Sep 9.

DOI:10.1007/s10557-024-07629-2
PMID:39249196
Abstract
摘要

相似文献

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Clopidogrel: Drug of the Past or Drug of the Future?氯吡格雷：过去的药物还是未来的药物？
Cardiovasc Drugs Ther. 2024 Dec;38(6):1073-1076. doi: 10.1007/s10557-024-07629-2. Epub 2024 Sep 9.
2
Antiplatelet effects of clopidogrel compared with aspirin after myocardial infarction: enhanced inhibitory effects of combination therapy.心肌梗死后氯吡格雷与阿司匹林抗血小板作用比较：联合治疗增强抑制作用
J Am Coll Cardiol. 2000 Sep;36(3):699-705. doi: 10.1016/s0735-1097(00)00817-2.
3
Clopidogrel in secondary ischemic stroke prevention.氯吡格雷用于二级缺血性卒中预防
Recent Pat Cardiovasc Drug Discov. 2008 Jun;3(2):119-25. doi: 10.2174/157489008784705340.
4
Clopidogrel with proton pump inhibitors: safe or not?氯吡格雷与质子泵抑制剂：安全吗？
Clin Cardiol. 2011 Sep;34(9):528-31. doi: 10.1002/clc.20928. Epub 2011 Jun 29.
5
Treatment options for patients with poor clopidogrel response.对氯吡格雷反应不佳的患者的治疗选择。
Cardiol Rev. 2013 Nov-Dec;21(6):309-17. doi: 10.1097/CRD.0b013e3182a72fab.
6
Inhibition of the antithrombotic effects of clopidogrel by proton pump inhibitors: facts or fancies?质子泵抑制剂对氯吡格雷抗血栓作用的抑制：事实还是想象？
Eur J Intern Med. 2010 Dec;21(6):484-9. doi: 10.1016/j.ejim.2010.08.004. Epub 2010 Sep 16.
7
Randomised clinical trial: rabeprazole plus aspirin is not inferior to rabeprazole plus clopidogrel for the healing of aspirin-related peptic ulcer.随机临床试验：雷贝拉唑加阿司匹林在治疗阿司匹林相关消化性溃疡方面并不逊于雷贝拉唑加氯吡格雷。
Aliment Pharmacol Ther. 2011 Sep;34(5):519-25. doi: 10.1111/j.1365-2036.2011.04760.x. Epub 2011 Jul 5.
8
Clopidogrel resistance: fact and fiction.氯吡格雷抵抗：事实与假象
Future Cardiol. 2006 Mar;2(2):215-28. doi: 10.2217/14796678.2.2.215.
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Use of Clopidogrel and Proton Pump Inhibitors Alone or in Combinations in Persons with Diabetes in Denmark; Potential for CYP2C19 Genotype-Guided Drug Therapy.丹麦糖尿病患者单独或联合使用氯吡格雷和质子泵抑制剂；CYP2C19基因型指导药物治疗的潜力。
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Poor response to clopidogrel: current and future options for its management.氯吡格雷反应不佳：其管理的当前和未来选择。
J Thromb Thrombolysis. 2010 Oct;30(3):319-31. doi: 10.1007/s11239-010-0457-5.

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Treatment of non-ST-segment elevation myocardial infarction in the elderly: the SENIOR-RITA trial.老年非ST段抬高型心肌梗死的治疗：SENIOR-RITA试验
Eur Heart J Suppl. 2025 Apr 16;27(Suppl 3):iii131-iii136. doi: 10.1093/eurheartjsupp/suaf031. eCollection 2025 Mar.

本文引用的文献

1
Clopidogrel induced reduction in neutrophil count: An overlooked beneficial effect?氯吡格雷导致的中性粒细胞计数减少：被忽视的有益作用？
Eur J Intern Med. 2024 Jun;124:32-34. doi: 10.1016/j.ejim.2024.03.026. Epub 2024 Apr 6.
2
Ticagrelor or Clopidogrel Monotherapy vs Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: A Systematic Review and Patient-Level Meta-Analysis.替格瑞洛或氯吡格雷单药治疗与经皮冠状动脉介入治疗后双联抗血小板治疗：系统评价和患者水平荟萃分析。
JAMA Cardiol. 2024 May 1;9(5):437-448. doi: 10.1001/jamacardio.2024.0133.
3
Beyond association: high neutrophil counts are a causal risk factor for atherosclerotic cardiovascular disease.
超越关联：高中性粒细胞计数是动脉粥样硬化性心血管疾病的一个因果风险因素。
Eur Heart J. 2023 Dec 14;44(47):4965-4967. doi: 10.1093/eurheartj/ehad711.
4
Clopidogrel vs Aspirin Monotherapy Beyond 1 Year After Percutaneous Coronary Intervention.氯吡格雷与阿司匹林单药治疗在经皮冠状动脉介入治疗 1 年后。
J Am Coll Cardiol. 2024 Jan 2;83(1):17-31. doi: 10.1016/j.jacc.2023.10.013. Epub 2023 Oct 23.
5
2023 ESC Guidelines for the management of acute coronary syndromes.2023年欧洲心脏病学会急性冠状动脉综合征管理指南。
Eur Heart J. 2023 Oct 12;44(38):3720-3826. doi: 10.1093/eurheartj/ehad191.
6
P2Y Inhibitor or Aspirin Monotherapy for Secondary Prevention of Coronary Events.P2Y 抑制剂或阿司匹林单药治疗用于冠心病事件的二级预防。
J Am Coll Cardiol. 2023 Jul 11;82(2):89-105. doi: 10.1016/j.jacc.2023.04.051.
7
Antithrombotic treatment strategies in patients with established coronary atherosclerotic disease.稳定性冠心病患者的抗血栓治疗策略。
Eur Heart J Cardiovasc Pharmacother. 2023 Jul 29;9(5):462-496. doi: 10.1093/ehjcvp/pvad032.
8
P2Y Inhibitor Monotherapy or Dual Antiplatelet Therapy After Complex Percutaneous Coronary Interventions.复杂经皮冠状动脉介入治疗后 P2Y 抑制剂单药治疗或双联抗血小板治疗。
J Am Coll Cardiol. 2023 Feb 14;81(6):537-552. doi: 10.1016/j.jacc.2022.11.041.
9
Aspirin Versus Clopidogrel for Long-Term Maintenance Monotherapy After Percutaneous Coronary Intervention: The HOST-EXAM Extended Study.经皮冠状动脉介入治疗后阿司匹林与氯吡格雷用于长期维持单药治疗：HOST-EXAM扩展研究
Circulation. 2023 Jan 10;147(2):108-117. doi: 10.1161/CIRCULATIONAHA.122.062770. Epub 2022 Nov 7.
10
Differential effect of clopidogrel and ticagrelor on leukocyte count in relation to patient characteristics, biomarkers and genotype: a PLATO substudy.氯吡格雷和替格瑞洛对白细胞计数的差异影响与患者特征、生物标志物和基因型的关系：一项PLATO亚组研究
Platelets. 2022 Apr 3;33(3):425-431. doi: 10.1080/09537104.2021.1934667. Epub 2021 Jun 2.