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瘢痕疙瘩核心切除技术的有效性:一项系统评价

Effectiveness of Core Excision Technique for Keloids: A Systematic Review.

作者信息

Ran Xiaoye, Guo Xiaoshuang, Liu Yuanbo, Zhu Shan, Li Shanshan, Chen Zixiang, Han Tinglu, Jin Shengyang, Zhou Mengqi, Zang Mengqing

机构信息

From the Scar and Wound Treatment Center.

Craniomaxillofacial Department, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College.

出版信息

Plast Reconstr Surg. 2025 Apr 1;155(4):801e-808e. doi: 10.1097/PRS.0000000000011733. Epub 2024 Sep 4.

Abstract

BACKGROUND

The keloid core excision technique mitigates the risk of wound tension and promotes favorable morphologic outcomes. However, whether residual keloid tissue or other factors increase the risk of recurrence remains unclear. This systematic review aimed to evaluate the therapeutic outcomes of core excision techniques for keloids.

METHODS

A systematic literature review was conducted by searching PubMed, Embase, Web of Science Core Collection, and Cochrane Library databases on July 30, 2023. The search terms used were "keloid," "core excision," "intralesional excision," "intramarginal excision," "rind flap," and "fillet flap." The inclusion criteria for the studies were established in advance and evaluated by multiple investigators.

RESULTS

Overall, 20 studies involving 926 keloid cases managed through core excision were included. Adjuvant therapies were used in 19 studies, with radiotherapies and steroid injections emerging as the predominant methods. The recurrence rates ranged from 0% to 28.6%. Residual scar tissue after core excision and complications, such as flap necrosis and hematoma, are the major factors contributing to recurrence.

CONCLUSIONS

The core excision technique is a surgical treatment of keloids with a low recurrence rate when combined with adjuvant therapies. However, randomized controlled trials and conclusive quantitative studies are necessary to further investigate the effects of the core excision technique on keloids.

摘要

背景

瘢痕疙瘩核心切除技术可降低伤口张力风险并促进良好的形态学结果。然而,残留的瘢痕疙瘩组织或其他因素是否会增加复发风险仍不清楚。本系统评价旨在评估瘢痕疙瘩核心切除技术的治疗效果。

方法

2023年7月30日,通过检索PubMed、Embase、Web of Science核心合集和Cochrane图书馆数据库进行了系统的文献综述。使用的检索词为“瘢痕疙瘩”“核心切除”“病损内切除”“边缘内切除”“皮瓣”和“鱼形皮瓣”。研究的纳入标准预先确定,并由多名研究人员进行评估。

结果

总体而言,纳入了20项涉及926例通过核心切除治疗的瘢痕疙瘩病例的研究。19项研究使用了辅助治疗,放疗和类固醇注射是主要方法。复发率在0%至28.6%之间。核心切除后残留的瘢痕组织以及皮瓣坏死和血肿等并发症是导致复发的主要因素。

结论

核心切除技术是一种治疗瘢痕疙瘩的手术方法,与辅助治疗联合使用时复发率较低。然而,需要进行随机对照试验和确定性定量研究,以进一步探究核心切除技术对瘢痕疙瘩的影响。

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