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多模态治疗方法改善了耳廓瘢痕疙瘩患者的临床预后。

A multimodal therapeutic approach improves the clinical outcome of auricular keloid patients.

机构信息

Department of Dermatology, Chinese PLA General Hospital, Beijing, China.

出版信息

Int J Dermatol. 2019 Jun;58(6):745-749. doi: 10.1111/ijd.14413. Epub 2019 Feb 27.

Abstract

OBJECTIVE

We retrospectively studied the efficacy of personalized therapy with surgical resection plus prophylactic management of postsurgical auricular keloids by intralesional injection of betamethasone and local pressure therapy using magnets in patients with auricular keloids.

METHODS

Surgical excision was performed in all patients, and surgical techniques including fusiform excision of the keloid scar, core excision of the keloid scar followed by flap repair, and scar graft were chosen.

RESULTS

A total of 85 patients with 98 auricular keloids were eligible. Seventy-two (74%) patients had primary auricular keloids, and 13 patients had recurrent keloids after surgical excision. Keloids, were located in the helix in 28 (32.9%) cases, in the earlobe in 45 (52.9%) cases, and in the entire auricle in 12 (14.1%) cases. The size of auricular keloids ranged from 10 to 35 mm. Surgical resection was uneventful in all cases. Twenty-one (21.4%) patients received fusiform excision, 47 (47.9%) patients underwent core excision and flap repair, and 30 (30.6%) patients received skin grafts. The patients were followed up for median duration of 1 year (range: 12-24 months). The cure rate was 87.2%, and the recurrence rate was 12.8%.

CONCLUSION

A personalized surgical approach based on the characteristics of auricular keloids in each patient and a multimodal therapeutic regimen including surgical excision, glucocorticoid blockade, and intralesional injection of glucocorticoids and pressure therapy improve the cure rate and reduce the recurrence rate of auricular keloids.

摘要

目的

我们回顾性研究了手术切除联合倍他米松瘤内注射和磁体局部压迫治疗耳瘢痕疙瘩预防性管理的个体化治疗对耳瘢痕疙瘩患者的疗效。

方法

所有患者均行手术切除,根据患者耳瘢痕疙瘩的特点选择手术技术,包括梭形切除瘢痕疙瘩、核心切除瘢痕疙瘩后皮瓣修复和瘢痕移植。

结果

共有 85 例 98 个耳瘢痕疙瘩患者符合条件。72 例(74%)患者为原发性耳瘢痕疙瘩,13 例患者为手术切除后复发的瘢痕疙瘩。28 例(32.9%)瘢痕疙瘩位于耳轮,45 例(52.9%)位于耳垂,12 例(14.1%)位于整个耳廓。耳瘢痕疙瘩的大小从 10 到 35 毫米不等。所有病例均顺利完成手术切除。21 例(21.4%)患者接受梭形切除,47 例(47.9%)患者接受核心切除和皮瓣修复,30 例(30.6%)患者接受皮肤移植。患者中位随访时间为 1 年(范围:12-24 个月)。治愈率为 87.2%,复发率为 12.8%。

结论

根据每位患者耳瘢痕疙瘩的特点制定个性化手术方案,并采用手术切除、糖皮质激素阻断、糖皮质激素瘤内注射和压迫治疗等多模式治疗方案,可提高治愈率,降低耳瘢痕疙瘩的复发率。

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