Chirurgia (Bucur). 2024 Aug;119(4):373-384. doi: 10.21614/chirurgia.3025.
This research describes an eight-year case-series of ovarian carcinoma by surgical (pTNM) staging and surgical procedure, explores the characteristics of ovarian surface epithelial cell (OSEC) tumours by histopathological type in a single centre of reference. Material and survival analysis with overall survivor probabilities for n=263 patients for 12 months and 60-month tumour free survival status (TFS). Results by staging (pTNM stage classification), histotype and for poor surgical candidate (PSC) status are shown. Histotype high grade serous carcinoma (HGSC) was the most frequently diagnosed type (63%). 12-month survivor probabilities according to histotype, rank as follows: clear cell carcinoma (CCC) - 14%; rare carcinoma (RC) - 15%; carcinosarcoma (CS) - 29%; HGSC - 46%; low grade serous carcinoma (LGSC) - 74%; endometrioid carcinoma (EC) - 79%; mucinous carcinoma (MC) - 80% and borderline tumours (BLT) - 94%. At 60 months results are: RC and MC - 0%; CCC - 14%; HGSC - 16%; CS - 29%; LGSC - 62%; EC - 66%; and BLT - 94%. Overall median survival time is 26 months (CI95% 15 to 37); and 20 months when BLT excluded (CI95% CI 15 to 25). These results may guide further research for the OSEC pathology and its histotypes.
本研究描述了一个 8 年的卵巢癌病例系列，通过手术（pTNM）分期和手术过程进行，探讨了单一参考中心上皮性卵巢肿瘤（OSEC）肿瘤的组织病理学类型特征。材料和生存分析，总体生存概率为 n=263 例，12 个月和 60 个月无肿瘤生存状态（TFS）。结果按分期（pTNM 分期分类）、组织类型和手术困难（PSC）状态进行显示。高级别浆液性癌（HGSC）是最常见的诊断类型（63%）。根据组织类型，12 个月的生存率如下：透明细胞癌（CCC）-14%；罕见癌（RC）-15%；癌肉瘤（CS）-29%；HGSC-46%；低级别浆液性癌（LGSC）-74%；子宫内膜样癌（EC）-79%；黏液性癌（MC）-80%和交界性肿瘤（BLT）-94%。60 个月的结果是：RC 和 MC-0%；CCC-14%；HGSC-16%；CS-29%；LGSC-62%；EC-66%；BLT-94%。总体中位生存时间为 26 个月（95%CI95% 15 至 37）；当排除 BLT 时为 20 个月（95%CI95% CI 15 至 25）。这些结果可能为 OSEC 病理学及其组织学类型的进一步研究提供指导。
