Wang Feng, Su Yanling, Yao Xiyu, Liu Jie, Ke Qingxian
Department of Head and Neck Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China.
Developmental Behavioral Pediatrics Department, Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), Fuzhou, China.
Am Surg. 2025 Feb;91(2):186-190. doi: 10.1177/00031348241282710. Epub 2024 Sep 9.
Thyroid cancer (TC) is a highly prevalent malignant tumor of the head and neck. Papillary thyroid carcinoma (PTC) is the primary pathological type of TC, accounting for more than 80% of all TCs. mutations are closely associated with PTC. However, the relationship among HT, PTC, and mutations has not yet been clarified. We aimed to investigate the mutation in Hashimoto's thyroiditis (HT) with PTC.
A total of 72 patients with multifocal PTC were included and grouped based on surgical pathology examination. Group A (n = 32) had pure multifocal PTC and Group B (n = 40) had HT with multifocal PTC. Various features were compared: mutation, multifactorial analysis of mutations, pathological features in patients with HT and multifocal PTC, and multifactorial analysis of factors affecting HT with multifocal PTC.
Significant differences were seen in thyroid peroxidase antibody levels, central lymph node metastasis, extra-thyroidal invasion, main and non-main lesion diameters, and mutation positivity ( < 0.05). Patients with the mutation had significantly higher rates of extra-thyroidal invasion and lymph node metastasis than those without the mutation ( < 0.05). Logistic regression analysis showed that mutation and main lesion nodule diameter were independent risk factors affecting extra-thyroidal invasion and central lymph node metastasis in patients with HT and multifocal PTC ( < 0.05).
mutations were more prevalent and closely associated with extra-thyroidal invasion and central lymph node metastasis in patients with HT and multifocal PTC.
甲状腺癌（TC）是头颈部一种高度常见的恶性肿瘤。乳头状甲状腺癌（PTC）是TC的主要病理类型，占所有TC的80%以上。[此处原文缺失具体基因名称]突变与PTC密切相关。然而，桥本甲状腺炎（HT）、PTC和[此处原文缺失具体基因名称]突变之间的关系尚未阐明。我们旨在研究合并PTC的桥本甲状腺炎（HT）中的[此处原文缺失具体基因名称]突变。
共纳入72例多灶性PTC患者，并根据手术病理检查进行分组。A组（n = 32）为单纯多灶性PTC，B组（n = 40）为合并多灶性PTC的HT。比较了各种特征：[此处原文缺失具体基因名称]突变、[此处原文缺失具体基因名称]突变的多因素分析、HT合并多灶性PTC患者的病理特征以及影响HT合并多灶性PTC的因素的多因素分析。
甲状腺过氧化物酶抗体水平、中央淋巴结转移、甲状腺外侵犯、主要和非主要病灶直径以及[此处原文缺失具体基因名称]突变阳性率方面存在显著差异（P < 0.05）。有[此处原文缺失具体基因名称]突变患者的甲状腺外侵犯和淋巴结转移率显著高于无[此处原文缺失具体基因名称]突变患者（P < 0.05）。Logistic回归分析表明，[此处原文缺失具体基因名称]突变和主要病灶结节直径是影响HT合并多灶性PTC患者甲状腺外侵犯和中央淋巴结转移的独立危险因素（P < 0.05）。
[此处原文缺失具体基因名称]突变在HT合并多灶性PTC患者中更为普遍，且与甲状腺外侵犯和中央淋巴结转移密切相关。
