HLA - B*58:01限制性CD8 + T细胞在HIV - 1 A/E亚型感染中的作用

Role of HLA-B*58:01-Restricted CD8+ T Cells in HIV-1 Subtype AE Infection.

作者信息

Nguyen Hung The, Chikata Takayuki, Zhang Yu, Van Tran Giang, Gatanaga Hiroyuki, Oka Shinichi, Takiguchi Masafumi

机构信息

Divisions of International Collaboration Research and Tokyo Joint Laboratory, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto/Tokyo, Japan.

Department of General Planning, National Hospital of Tropical Diseases, Hanoi, Vietnam.

出版信息

J Infect Dis. 2025 Feb 4;231(1):175-185. doi: 10.1093/infdis/jiae448.

DOI:10.1093/infdis/jiae448

PMID:39250760

Abstract

HLA-B58:01 and HLA-B57 are protective alleles against human immunodeficiency virus type 1 (HIV-1) subtype B or C infection, whereas these HLA alleles have not been reported as protective in HIV-1 subtype AE infection. Although HLA-B58:01-restricted and HLA-B57-restricted HIV-1-specific CD8+ T cells have been thoroughly analyzed in subtype B or C infection, they have been only partially analyzed in subtype AE infection. We identified 6 HLA-B58:01-restricted subtype AE epitopes in Vietnamese individuals infected with subtype AE. HLA-B58:01-restricted T-cell responses to Gag epitopes, which may control disease progression in HLA-B58:01+ and HLA-B57+ individuals infected with subtype B or C, were not protective in subtype AE infection. These findings suggest that the loss of HLA-B58:01-restricted T cells specific for some Gag epitopes and/or their reduced ability may account for the lack of protective effects conferred by HLA-B58:01 in subtype AE infection.

摘要

HLA - B58:01和HLA - B57是针对1型人类免疫缺陷病毒（HIV - 1）B亚型或C亚型感染的保护性等位基因，而这些HLA等位基因在HIV - 1 AE亚型感染中尚未被报道具有保护作用。尽管在B亚型或C亚型感染中已对HLA - B58:01限制性和HLA - B57限制性的HIV - 1特异性CD8 + T细胞进行了全面分析，但在AE亚型感染中仅进行了部分分析。我们在感染AE亚型的越南个体中鉴定出6个HLA - B58:01限制性AE亚型表位。HLA - B58:01限制性T细胞对Gag表位的反应，在感染B亚型或C亚型的HLA - B58:01+和HLA - B57+个体中可能控制疾病进展，但在AE亚型感染中并无保护作用。这些发现表明，某些Gag表位特异性的HLA - B58:01限制性T细胞的缺失和/或其功能降低，可能是HLA - B58:01在AE亚型感染中缺乏保护作用的原因。