Stoncius L V, Ashrafi S H, Meyer J
J Oral Pathol. 1985 May;14(5):375-82. doi: 10.1111/j.1600-0714.1985.tb00508.x.
As previously reported, young rats on zinc-deficient diets develop a marked epithelial hyperplasia in the mucosa of the cheek, associated with a four-fold increase in the number of mast cells in the lamina propria. We now report the results of a quantitative and qualitative ultrastructural study of these mast cells. In contrast to the cells in mast cell-related disease, the cells were of normal morphology, but of consistently increased size, containing proportionally increased numbers of mitochondria and specific granules. The size distribution of the granules was as in controls. Microvilli were lengthened in proportion to the increase in the cell circumference. The number of nuclear pores was increased but their spacing was as in controls. In all these measurements, the experimental mast cells were a remarkably homogeneous population. We conclude that mast cells are capable of developing into cells of larger size showing evidence of greater activity. It may be that this development occurs in response to the same (unknown) stimulus which causes their number to increase. By virtue of their increased number and size, mast cells may play an important role in the enhancement of the microcirculation commonly seen in conditions of epithelial hyperplasia.
如先前报道，食用缺锌日粮的幼鼠在颊黏膜出现明显的上皮增生，同时固有层中肥大细胞数量增加四倍。我们现在报告对这些肥大细胞进行的定量和定性超微结构研究结果。与肥大细胞相关疾病中的细胞不同，这些细胞形态正常，但大小持续增加，线粒体数量和特异性颗粒数量相应增加。颗粒的大小分布与对照组相同。微绒毛长度与细胞周长的增加成比例延长。核孔数量增加但其间距与对照组相同。在所有这些测量中，实验性肥大细胞是一个非常均匀的群体。我们得出结论，肥大细胞能够发育成更大尺寸的细胞，显示出活性增强的迹象。可能这种发育是对导致其数量增加的相同（未知）刺激的反应。由于数量和大小的增加，肥大细胞可能在上皮增生情况下常见的微循环增强中起重要作用。
