Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, 4th Gansu Road, Heping District, Tianjin, 30020, PR China.
BMC Ophthalmol. 2024 Sep 9;24(1):400. doi: 10.1186/s12886-024-03655-8.
We aimed to evaluate microaneurysms (MAs) after treatment with anti-vascular endothelial growth factor (anti-VEGF) therapy to understand causes of chronic edema and anti-VEGF resistance.
Patients with non-proliferative diabetic retinopathy, with or without macular edema were recruited. Optical coherence tomography angiography (OCTA) MAs-related parameters were observed, including the maximum diameter of overall dimensions, material presence, and flow signal within the lumen. OCTA parameters also included central macular thickness (CMT), foveal avascular zone, superficial and deep capillary plexuses, and non-flow area measurements on the superficial retinal slab.
Overall, 48 eyes from 43 patients were evaluated. CMT differed significantly between the diabetic macular edema (DME ) and non-DME (NDME) groups at 1st, 2nd, 3rd, and 6th months of follow-up (P < 0.001; <0.001; 0.003; <0.001, respectively). A total of 55 and 59 MAs were observed in the DME (mean = 99.40 ± 3.18 μm) and NDME (mean maximum diameter = 74.70 ± 2.86 μm) groups at baseline, respectively (significant between-group difference: P < 0.001). Blood flow signal was measurable for 46 (83.6%) and 34 (59.3%) eyes in the DME and NDME groups, respectively (significant between-group difference: P < 0.001).
Compared to the NDME group, the DME group had larger MAs and a higher blood-flow signal ratio. Following anti-VEGF therapy, changes in the diameter of MAs were observed before changes in CMT thickness.
我们旨在评估抗血管内皮生长因子（anti-VEGF）治疗后微动脉瘤（MAs）的变化，以了解慢性水肿和抗 VEGF 抵抗的原因。
招募患有非增生性糖尿病视网膜病变，伴或不伴黄斑水肿的患者。观察光学相干断层扫描血管造影（OCTA）MAs 相关参数，包括整体尺寸的最大直径、物质存在和管腔内部的血流信号。OCTA 参数还包括中心黄斑厚度（CMT）、中心无血管区、浅层和深层毛细血管丛以及浅层视网膜片上的无血流区域测量值。
共有 43 名患者的 48 只眼接受了评估。在第 1、2、3 和 6 个月的随访中，糖尿病性黄斑水肿（DME）和非糖尿病性黄斑水肿（NDME）组的 CMT 差异有统计学意义（P < 0.001；<0.001；0.003；<0.001）。在 DME（平均= 99.40 ± 3.18 μm）和 NDME（平均最大直径= 74.70 ± 2.86 μm）组中，基线时分别观察到 55 和 59 个 MAs（两组之间存在显著差异：P < 0.001）。在 DME 和 NDME 组中，分别有 46（83.6%）和 34（59.3%）只眼可测量血流信号（两组之间存在显著差异：P < 0.001）。
与 NDME 组相比，DME 组的 MAs 更大，血流信号比更高。在接受抗 VEGF 治疗后，CMT 厚度变化之前观察到 MAs 直径的变化。
