Department of İnternal Medicine, Yüreğir Public Hospital, Adana, Turkey.
Department of Cardiology, Başkent University Hospital, Adana, Turkey.
Medicine (Baltimore). 2024 Sep 6;103(36):e38741. doi: 10.1097/MD.0000000000038741.
The goal is to provide foundational data that could spearhead more extensive, prospective research into understanding the influences of micronutrient levels on the nocturnal patterns of hypertension, possibly aiding in identifying potential therapeutic strategies to reduce cardiovascular risk in this demographic. The research employed a retrospective design to analyze the micronutrient levels, including ferritin, folic acid, vitamin B12, and vitamin D, in a limited sample size from a single hospital. However, it is worth noting that the study did not scrutinize other potentially relevant micronutrients and biomarkers and lacked information on potential confounding factors such as lifestyle and dietary habits, physical activity levels, and specific details on antihypertensive medications used. The preliminary findings highlight a significant difference in ferritin levels between dipper and non-dipper groups, indicating a potential role in the development of non-dipper hypertension. Surprisingly, no notable difference was observed in vitamin D levels between the groups. The study underscores the increasing prevalence of hypertension and micronutrient deficiencies as age progresses. Despite its limitations, including limited sample size and potential influences from unaccounted variables, the study hints at a potential relationship between micronutrient levels and non-dipper hypertension. It emphasizes the necessity for larger scale, prospective research to delve deeper into the nature of this relationship, potentially fostering new therapeutic approaches in cardiovascular risk management within the elderly population.
目的在于提供基础性数据,为更广泛的前瞻性研究奠定基础,以深入了解微量营养素水平对夜间高血压模式的影响,从而可能有助于确定针对该人群降低心血管风险的潜在治疗策略。该研究采用回顾性设计,分析了单个医院小样本量的微量营养素水平,包括铁蛋白、叶酸、维生素 B12 和维生素 D。然而,值得注意的是,该研究并未详细研究其他潜在相关的微量营养素和生物标志物,也缺乏关于潜在混杂因素(如生活方式和饮食习惯、身体活动水平以及所用降压药物的具体信息)的信息。初步研究结果表明,杓型和非杓型组之间的铁蛋白水平存在显著差异,表明其在非杓型高血压的发展中可能发挥作用。令人惊讶的是,两组间维生素 D 水平无明显差异。该研究强调了随着年龄的增长,高血压和微量营养素缺乏症的发病率不断上升。尽管存在局限性,包括样本量有限以及未考虑到的变量可能产生的影响,但该研究提示微量营养素水平与非杓型高血压之间可能存在关联。它强调了进行更大规模、前瞻性研究的必要性,以深入探究这种关系的本质,从而可能为老年人群的心血管风险管理提供新的治疗方法。