Department of Immunohaematology Diagnostic Services, Sanquin Diagnostic Services, Amsterdam, The Netherlands.
Department of Laboratory Medicine, University Medical Center Groningen (UMCG), Groningen, The Netherlands.
Br J Haematol. 2024 Oct;205(4):1599-1604. doi: 10.1111/bjh.19740. Epub 2024 Sep 10.
Extension with cE-matching of the transfusion policy for women under 45 years to prevent alloimmunization and hemolytic disease of the foetus and newborn (HDFN) was evaluated. After implementation of cEK-matching, anti-c occurrence decreased from 46.8 to 30.4 per 100 000 pregnancies (RR 0.65, 95% CI 0.54-0.79), while anti-E occurrence decreased from 122.1 to 89.9 per 100 000 pregnancies (RR 0.74, 95% CI 0.66-0.84). The c-negative women showed a higher anti-E occurrence before cEK-matching and a more pronounced decline with the new policy. This indicates that cEK-matched transfusion effectively reduces alloimmunization, and that a cK-matched approach could prevent most transfusion-related alloimmunization and HDFN.
评估了延长年龄在 45 岁以下的女性输血策略以预防同种免疫和胎儿及新生儿溶血病（HDFN）的 cE 配型的效果。在实施 cEK 配型后，每 100000 例妊娠中抗-c 的发生从 46.8 例降至 30.4 例（RR 0.65，95%CI 0.54-0.79），而抗-E 的发生从 122.1 例降至 89.9 例（RR 0.74，95%CI 0.66-0.84）。cE 阴性女性在 cEK 配型前的抗-E 发生率更高，而新政策的效果更为明显。这表明 cEK 配型的输血策略可有效减少同种免疫，cK 配型的方法可以预防大多数与输血相关的同种免疫和 HDFN。
