诱导方案强度和异基因造血干细胞移植对费城染色体阳性急性淋巴细胞白血病患者生存的影响：一项多机构研究。
Impact of induction regimens intensity and allogeneic stem cell transplantation on survival of patients with Philadelphia chromosome-positive acute lymphoblastic leukemia: A multi-institutional study.
机构信息
Division of Hematology-Oncology and Blood and Marrow Transplantation and Cellular Therapy Program, Mayo Clinic, Jacksonville, Florida, USA.
Division of Hematology and Medical Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
出版信息
Am J Hematol. 2024 Dec;99(12):2388-2391. doi: 10.1002/ajh.27475. Epub 2024 Sep 10.
PMID:39253997
Abstract
Intensive chemotherapy (IC) combination with second- or third-generation TKI improves survival compared to non-IC with first-generation TKI. Allo-HCT was suggestive of improving RFS/OS after propensity score matching and multivariable analysis.
摘要
强化化疗（IC）联合第二代或第三代 TKI 比第一代 TKI 非 IC 改善生存。在倾向评分匹配和多变量分析后，异基因造血干细胞移植（allo-HCT）提示可改善无复发生存率（RFS）/总生存期（OS）。
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