DNA 损伤反应的 DNA 甲基化变异与黑色素瘤的生存和局部免疫状态相关。
DNA methylation variations of DNA damage response correlate survival and local immune status in melanomas.
机构信息
Department of Burns and Plastic Surgery, Changzhou Wujin People's Hospital, Changzhou, China.
Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
出版信息
Immun Inflamm Dis. 2024 Sep;12(9):e1331. doi: 10.1002/iid3.1331.
AIM
We aimed to explore the impact of DNA methylation alterations on the DNA damage response (DDR) in melanoma prognosis and immunity. MATERIAL & METHODS: Different melanoma cohorts with molecular and clinical data were included.
RESULTS
Hierarchical clustering utilizing different combinations of DDR-relevant CpGs yielded distinct melanoma subtypes, which were characteristic of different prognoses, transcriptional function profiles of DDR, and immunity and immunotherapy responses but were associated with similar tumor mutation burdens. We then constructed and validated a clinically applicable 4-CpG risk-score signature for predicting survival and immunotherapy response.
CONCLUSION
Our study describes the close interrelationship among DNA methylation, DDR machinery, local tumor immune status, melanoma prognosis, and immunotherapy response.
目的
本研究旨在探索 DNA 甲基化改变对黑色素瘤预后和免疫中 DNA 损伤反应（DDR）的影响。
材料与方法
纳入了具有分子和临床数据的不同黑色素瘤队列。
结果
利用不同 DDR 相关 CpG 的组合进行层次聚类，可产生不同的黑色素瘤亚型，这些亚型具有不同的预后、DDR 转录功能特征以及对免疫和免疫治疗的反应，但与相似的肿瘤突变负担相关。然后，我们构建并验证了一个临床上可应用的 4-CpG 风险评分signature，用于预测生存和免疫治疗反应。
结论
本研究描述了 DNA 甲基化、DDR 机制、局部肿瘤免疫状态、黑色素瘤预后和免疫治疗反应之间的密切关系。
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