Nuzhdin Alexey L, Bukhtiyarova Marina V, Bukhtiyarova Galina A
Boreskov Institute of Catalysis SB RAS, Novosibirsk 630090, Russia.
Org Biomol Chem. 2024 Oct 9;22(39):7936-7950. doi: 10.1039/d4ob00873a.
Flow hydrogenation performed over heterogeneous catalysts makes organic synthesis more economical, safe and environmentally friendly. Over the past two decades, a significant amount of research with a major focus on noble metal catalysts has been carried out in this area. However, catalysts based on non-noble metals (Ni, Cu, Co, .) are more promising for practical use due to their low cost and high availability. This review article discusses the use of supported and bulk non-noble metal catalysts for the liquid-phase hydrogenation of bi- and polyfunctional organic compounds in flow mode. The main attention is paid to the selective reduction of one functional group (NO, CC, CN, CO, and CN) in the presence of other substituents. In addition, cascade synthetic protocols involving hydrogenation are presented.
在多相催化剂上进行的流动氢化使有机合成更经济、安全且环保。在过去二十年中，该领域开展了大量主要聚焦于贵金属催化剂的研究。然而，基于非贵金属（镍、铜、钴等）的催化剂因其低成本和高可得性而在实际应用中更具前景。这篇综述文章讨论了负载型和块状非贵金属催化剂在流动模式下用于双官能和多官能有机化合物的液相加氢。主要关注在其他取代基存在下一个官能团（硝基、碳碳双键、碳氮双键、碳氧双键和碳氮单键）的选择性还原。此外，还介绍了涉及氢化的串联合成方案。
