Keiding S, Andreasen P B
Pharmacology. 1979;19(3):105-10. doi: 10.1159/000137296.
This review emphasizes the need for well-defined models for hepatic pharmacokinetics and discusses the interpretation of hepatic clearance measurements. Such recent approaches are subjected to theoretical and experimental comparisons. The pharmacokinetic consequences, including a classification of drugs according to hepatic clearance, are outlined.
本综述强调了建立明确的肝脏药代动力学模型的必要性，并讨论了肝脏清除率测量结果的解读。对这些最新方法进行了理论和实验比较。概述了药代动力学后果，包括根据肝脏清除率对药物进行分类。
