表观遗传重编程使 NF1A/B 在 SHH 髓母细胞瘤中发挥致癌作用。
Epigenetic reprogramming enables NF1A/B oncogenic role in SHH medulloblastoma.
机构信息
Brain Tumour Research Centre, Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.
Brain Tumour Research Centre, Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK; Barts Brain Tumour Centre, Faculty of Medicine and Dentistry, Queen Mary University of London and Barts Health NHS Trust, London, UK.
出版信息
Dev Cell. 2024 Sep 9;59(17):2275-2276. doi: 10.1016/j.devcel.2024.07.002.
In this issue of Developmental Cell, Shiraishi et al. investigate the epigenetic changes occurring during the formation of SHH medulloblastoma and show that an epigenomic shift renders Nuclear Factor I family of transcription factors oncogenic.
在本期《发育细胞》中，Shiraishi 等人研究了发生在 SHH 髓母细胞瘤形成过程中的表观遗传变化，并表明表观基因组重排使核因子 I 家族转录因子致癌。
Zotero 插件