Clarke-Pearson D L, Coleman R E, Siegel R, Synan I S, Petry N
Surgery. 1985 Jul;98(1):98-104.
Indium 111 platelet imaging for the detection of deep vein thrombosis and pulmonary emboli was performed in 171 patients after abdominal and pelvic surgery. Fifteen patients were found to have inadequate circulating blood pools of indium 111 platelets, making the study nondiagnostic. Of 156 patients with technically satisfactory images, 46 (29.5%) had images consistent with deep venous thrombosis and/or pulmonary emboli. The incidence, time of occurrence, and location of thromboemboli was similar to those of other reports of postoperative patients groups studied by iodine 125 fibrinogen uptake testing. Eighty patients had normal indium 111 platelets and 30 patients had diffusely distributed indium 111 platelets found in the operative field, suggesting accumulation in a postoperative hematoma. None of these results was confused with a diagnosis of deep venous thrombosis. When compared with another accurate diagnostic test in 23 patients, indium 111 platelet imaging was found to have a sensitivity of 100% and specificity of 90%. The technique of indium 111 platelet imaging is performed easily in patients after surgery with some limitations as to the use of donor platelets and the occasionally altered imaging of the operative site. This diagnostic technique enjoys the distinct advantage in that it allows surveillance of the legs, pelvis, abdomen, and chest by a single method, making it a near-ideal method of postoperative thromboembolism surveillance.
对171例腹部和盆腔手术后的患者进行了铟111血小板成像，以检测深静脉血栓形成和肺栓塞。发现15例患者铟111血小板的循环血池不足，导致研究无法诊断。在156例图像技术上令人满意的患者中，46例（29.5%）的图像与深静脉血栓形成和/或肺栓塞一致。血栓栓塞的发生率、发生时间和部位与其他通过碘125纤维蛋白原摄取试验研究的术后患者组的报告相似。80例患者铟111血小板正常，30例患者在手术区域发现铟111血小板弥漫分布，提示在术后血肿中积聚。这些结果均未与深静脉血栓形成的诊断相混淆。与23例患者的另一种准确诊断试验相比，发现铟111血小板成像的敏感性为100%，特异性为90%。铟111血小板成像技术在术后患者中操作简便，但在供体血小板的使用以及手术部位偶尔改变的成像方面存在一些局限性。这种诊断技术具有明显的优势，即它允许通过单一方法对腿部、骨盆、腹部和胸部进行监测，使其成为术后血栓栓塞监测的近乎理想的方法。
