Simonney N, De Bosch N, Argueyo A, Garcia E, Layrisse Z
Tissue Antigens. 1985 Apr;25(4):216-9. doi: 10.1111/j.1399-0039.1985.tb00440.x.
Twenty-eight unrelated hemophilia A patients, seven of them with anti-factor VIII antibodies were typed for HLA-A, B, C antigens and 25 of them for HLA-DR. The results show a significant difference in HLA-DR4 frequency between hemophiliacs with antibodies who lack this antigen and hemophiliacs without antibodies, in whom HLA-DR4 is increased as compared to a healthy control series. This data suggests that DR4 may be associated with a factor preventing anti-factor VIII immunization.
28名非亲属血友病A患者，其中7名有抗凝血因子VIII抗体，对他们进行了HLA - A、B、C抗原分型，25名进行了HLA - DR分型。结果显示，缺乏该抗原的有抗体血友病患者与无抗体血友病患者相比，HLA - DR4频率存在显著差异，与健康对照系列相比，无抗体血友病患者中HLA - DR4频率升高。该数据表明，DR4可能与一种阻止抗凝血因子VIII免疫的因素相关。
