利用免疫系统：对抗神经退行性疾病的疫苗

Harnessing the immune system: vaccines to fight neurodegenerative diseases.

作者信息

Gonzalez-Artero Alba, Pujols Jordi, Ventura Salvador

机构信息

Institut de Biotecnologia i de Biomedicina and Departament de Bioquímica i de Biologia Molecular, Universitat Autònoma de Barcelona, 08193 Bellaterra, (Barcelona), Spain.

出版信息

Trends Mol Med. 2025 Mar;31(3):209-212. doi: 10.1016/j.molmed.2024.08.005. Epub 2024 Sep 9.

DOI:10.1016/j.molmed.2024.08.005

PMID:39256108

Abstract

Neurodegenerative diseases strongly impact our aging society, with treatments providing only symptomatic relief. Recent advancements in active immunotherapy offer solutions by stimulating the immune system to produce antibodies against misfolded and toxic amyloid proteins. We discuss vaccines under clinical evaluation for Alzheimer's and Parkinson's diseases, highlighting successes and ongoing trials.

摘要

神经退行性疾病对我们的老龄化社会产生了重大影响，目前的治疗方法仅能缓解症状。主动免疫疗法的最新进展通过刺激免疫系统产生针对错误折叠和有毒淀粉样蛋白的抗体提供了解决方案。我们讨论了正在进行临床评估的针对阿尔茨海默病和帕金森病的疫苗，重点介绍了取得的成功和正在进行的试验。