交感神经切除术对虹膜酪氨酸酶活性的影响。

The effect of sympathectomy upon iris tyrosinase activity.

作者信息

Lloyd T, Kochel R L, Weinstein J M

出版信息

Vision Res. 1985;25(2):213-7. doi: 10.1016/0042-6989(85)90115-4.

Abstract

It is generally accepted that interruption of the sympathetic pathway to the eye may result in iris hypochromia in human infants. Weanling Dutch belted rabbits were used as a model system to investigate whether the melanin synthesizing enzyme, tyrosinase, is regulated in the iris of the juvenile animal by adrenergic innervation. Although we did not find a significant decrease in tyrosine activity isolated from the sympathetically denervated iris, we did observe a tenfold fall in iris tyrosine activity between the 30th and 120th days of life in both intact and denervated irides. About 90% of the iris tyrosine activity was localized in the pigmented epithelium and the remaining tyrosinase activity was found in the stromal tissue. This distribution of tyrosine activity was not affected by sympathetic denervation or time.

摘要

人们普遍认为，切断通向眼睛的交感神经通路可能会导致人类婴儿虹膜色素减退。断奶期的荷兰带兔被用作模型系统，以研究黑色素合成酶酪氨酸酶在幼年动物的虹膜中是否受肾上腺素能神经支配的调节。尽管我们没有发现从交感神经去神经支配的虹膜中分离出的酪氨酸活性有显著降低，但我们确实观察到，在出生后第30天至120天期间，完整和去神经支配的虹膜中，虹膜酪氨酸活性下降了10倍。约90%的虹膜酪氨酸活性定位于色素上皮，其余的酪氨酸酶活性存在于基质组织中。酪氨酸活性的这种分布不受交感神经去神经支配或时间的影响。