Clin Lab. 2024 Sep 1;70(9). doi: 10.7754/Clin.Lab.2024.240438.
Group A Streptococcus causes a variety of human infections, including the life-threatening necrotizing fasciitis, which may be ignored by the patient. From hours to days, the infection may progress from an apparently benign skin lesion, usually mistaken for a spider or insect bite, to a highly lethal disease. We present a case of 57-year-old male with skin lesions on swelling left upper limb.
The culture of secretion from epidermis and blood were positive for Group A Streptococcus (GAS), type β hemolytic streptococcus. Intensive anti-infection therapy was applied. However, the necrosis of the limb deteriorated rapidly. He died from multiple organ failure, streptococcal toxic shock syndrome (STSS) and disseminated intravascular coagulation 13 days later.
Necrotizing fasciitis is a rapidly progressive, destructive bacterial infection. Early recognition is the most important factor for survival.
A 组链球菌可引起多种人类感染，包括危及生命的坏死性筋膜炎，患者可能会忽略这种感染。从几小时到几天，感染可能会从看似良性的皮肤病变发展而来，通常被误诊为蜘蛛或昆虫叮咬，进而发展为高度致命的疾病。我们报告了一例 57 岁男性病例，其左侧上肢肿胀处有皮肤病变。
表皮和血液分泌物的培养均为 A 组链球菌（GAS）、β型溶血性链球菌阳性。给予强化抗感染治疗。然而，肢体的坏死迅速恶化。13 天后，他因多器官衰竭、链球菌中毒性休克综合征（STSS）和弥漫性血管内凝血而死亡。
坏死性筋膜炎是一种迅速进展、破坏性的细菌性感染。早期识别是生存的最重要因素。
