Clin Lab. 2024 Sep 1;70(9). doi: 10.7754/Clin.Lab.2024.240404.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection typically relies on reverse transcription-polymerase chain reaction (RT-PCR) technology. However, there is a certain rate of missed detection of SARS-CoV-2 in nasopharyngeal samples, particularly among immunosuppressed individuals.
In this case, SARS-CoV-2 was detected in nasopharyngeal swabs and bronchoalveolar lavage fluid (BALF) using RT-PCR. Pulmonary imaging was performed using computed tomography (CT). Patient clinical data were retrieved from the Laboratory Information System (LIS).
SARS-CoV-2 was negative in two nasopharyngeal tests of the patient, but was finally detected in BALF, confirming that the lung lesions were infected by SARS-CoV-2.
In the post-epidemic era, it is necessary to use BALF to identify SARS-CoV-2 infection in cases where other factors have been ruled out in immunosuppressed individuals with pulmonary infections, especially when the nasopharyngeal test yields a negative result.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的检测通常依赖于逆转录-聚合酶链反应（RT-PCR）技术。然而，在鼻咽样本中，SARS-CoV-2 的检测存在一定的漏检率，尤其是在免疫抑制个体中。
本案例中，使用 RT-PCR 检测鼻咽拭子和支气管肺泡灌洗液（BALF）中的 SARS-CoV-2。采用计算机断层扫描（CT）进行肺部影像学检查。患者的临床数据从实验室信息系统（LIS）中提取。
患者的两次鼻咽拭子检测 SARS-CoV-2 均为阴性，但最终在 BALF 中检测到，证实肺部病变感染了 SARS-CoV-2。
在后疫情时代，对于免疫抑制的肺部感染患者，在排除其他因素后，若鼻咽拭子检测结果为阴性，需要使用 BALF 来识别 SARS-CoV-2 感染，尤其是在鼻咽拭子检测结果为阴性时。
